(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE
- Product Name
- (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE
- CAS No.
- 1218935-60-4
- Chemical Name
- (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE
- Synonyms
- (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HCL;(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE;(R)-2-(2,5-Difluorophenyl)pyrrolidene hydrochloride;Pyrrolidine, 2-(2,5-difluorophenyl)-, hydrochloride (1:1), (2R)-;(R)-2-(2,5-difluorophenyl)pyrrolidine (HCL salt form), 97%min, ee97%min
- CBNumber
- CB4816500
- Molecular Formula
- C10H12ClF2N
- Formula Weight
- 219.66
- MOL File
- Mol file
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1/C10H11F2N.ClH/c11-7-3-4-9(12)8(6-7)10-2-1-5-13-10;/h3-4,6,10,13H,1-2,5H2;1H/t10-;/s3
- InChIKey
- XSWCQOVADZHFIJ-MEQOOBBNNA-N
- SMILES
- FC1C=CC(F)=CC=1[C@@H]1NCCC1.Cl |&1:8,r|
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- R701405
- Product name
- (R)-2-(2,5-difluorophenyl)pyrrolidinehydrochloride
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 3H31-7-R3
- Product name
- (R)-2-(2,5-Difluorophenyl)pyrrolidinehydrochloride
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $186
- Updated
- 2021/12/16
- Product number
- PC201077
- Product name
- (R)-2-(2,5-Difluorophenyl)pyrrolidinehydrochloride
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $94
- Updated
- 2021/12/16
- Product number
- PC201077
- Product name
- (R)-2-(2,5-Difluorophenyl)pyrrolidinehydrochloride
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 3H31-7-R3
- Product name
- (R)-2-(2,5-Difluorophenyl)pyrrolidinehydrochloride
- Purity
- 95.0%
- Packaging
- 100mg
- Price
- $151
- Updated
- 2021/12/16
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride is a fine chemical that is useful as a building block in the synthesis of complex compounds.
Mechanism of action
In medicinal chemistry, (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE may interact with molecular targets such as enzymes, receptors, or ion channels, modulating their activity and leading to therapeutic effects. The presence of fluorine atoms can enhance the compound's binding affinity and selectivity for its target, contributing to its efficacy and potency.
Synthesis
1443538-31-5
1218935-60-4
The general procedure for the synthesis of (R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride from the compound (CAS: 1443538-31-5) was as follows: to a stirred solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (15 g, 52.19 mmol) in dioxane (25 mL) was added a 4 M HCl to a solution of dioxane (75 mL). The reaction mixture was stirred continuously at 20-35°C for 4 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by washing with ether to give 7.5 g of (R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride as a white solid. Mass spectrometry (ESI) analysis showed: m/z 184 (M + H).
References
[1] Patent: WO2013/88256, 2013, A1. Location in patent: Page/Page column 59
[2] Patent: US2014/371217, 2014, A1. Location in patent: Paragraph 0561
[3] Patent: US2015/5280, 2015, A1. Location in patent: Paragraph 0527 - 0529
[4] Patent: US2015/368238, 2015, A1. Location in patent: Paragraph 0574; 0579
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE manufacturers
- Product
- (R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride 1218935-60-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-06
- Product
- (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE 1218935-60-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- (R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride 1218935-60-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-26