(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE

Product Name: (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
CAS No.: 1218935-59-1
Chemical Name: (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
Synonyms: (R)-2-(2,5-difluorophenyl)pyrrolidine;Larotrectinib Pyrrolidine Impurity;(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE;(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL;Pyrrolidine, 2-(2,5-difluorophenyl)-, (2R)-;(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride;Larotrectinib Impurity 7（Larotrectinib Pyrrolidine Impurity）;(2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid
CBNumber: CB8277099
Molecular Formula: C10H11F2N
Formula Weight: 183.2
MOL File: Mol file

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(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Property

Boiling point:: 213.5±40.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.02±0.10(Predicted)
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D447875
Product name: (2R)-2-(2,5-Difluorophenyl)pyrrolidine
Packaging: 1g
Price: $560
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0038652
Product name: (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
Purity: 95.00%
Packaging: 0.25G
Price: $326
Updated: 2021/12/16

Chemenu

Product number: CM198812
Product name: (2R)-2-(2,5-Difluorophenyl)pyrrolidine
Purity: 95%
Packaging: 1g
Price: $407
Updated: 2021/12/16

Alichem

Product number: 1218935591
Product name: (R)-2-(2,5-Difluorophenyl)pyrrolidine
Packaging: 1g
Price: $435
Updated: 2021/12/16

ACHEMBLOCK

Product number: K12111
Product name: (2R)-2-(2,5-difluorophenyl)pyrrolidine
Purity: 95%
Packaging: 250MG
Price: $115
Updated: 2021/12/16

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(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Chemical Properties,Usage,Production

Uses

(2R)-2-(2,5-Difluorophenyl)pyrrolidine is used in the synthesis of imidazo[1,2-b]pyridazine compounds as inhibitors of Trk kinases.

Synthesis

1443538-31-5

1218935-59-1

GENERAL STEPS: To a solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (8.60 g, 29.9 mmol) in methanol (60 mL) was slowly added a dioxane solution (37.4 mL, 150 mmol) of 4M hydrochloric acid at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was concentrated under vacuum and the residue was dissolved in water (100 mL) and washed with ethyl acetate (100 mL). The aqueous layer was separated and neutralized with 1N aqueous sodium hydroxide (150 mL) followed by extraction with dichloromethane (100 mL × 3). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford (R)-2-(2,5-difluorophenyl)pyrrolidine (5.06 g, 92% yield) as a slightly reddish oil.1H-NMR (CDCl3, Varian, 400 MHz): δ 1.56-1.65 (1H, m), 1.78-1.93 (3H m), 2.21-2.30 (1H, m), 3.01-3.08 (1H, m), 3.13-3.18 (1H, m), 4.39 (1H, t, J = 7.6 Hz), 6.82-6.88 (1H, m), 6.91-6.97 (1H, m), 7.22-7.26 (1H, m).

References

[1] Patent: CN107286070, 2017, A. Location in patent: Paragraph 0079; 0080; 0081
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0207; 0215; 0216
[3] Patent: CN109053525, 2018, A. Location in patent: Paragraph 0021; 0031; 0032; 0033
[4] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0324; 0325; 0345-0347

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE Suppliers

China 159 India 1 United States 6 Global 166

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View Lastest Price from (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 1218935-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: (2R)-2-(2,5-Difluorophenyl)pyrrolidine 1218935-59-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 200kg
Release date: 2023-10-08

Nanjing Fred Technology Co., Ltd

Product: (2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride 1218935-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

1218935-59-1, (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINERelated Search:

TRIS(PENTAFLUOROPHENYL)PHOSPHINE 1-Methylpyrrolidine (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE

(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride

(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL

(R)-2-(2,5-difluorophenyl)pyrrolidine

Pyrrolidine, 2-(2,5-difluorophenyl)-, (2R)-

Larotrectinib Impurity 7（Larotrectinib Pyrrolidine Impurity）

Larotrectinib Pyrrolidine Impurity

(2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid

1218935-59-1