2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

Product Name: 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CAS No.: 2359705-88-5
Chemical Name: 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Synonyms: Lenalidomide-F;2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CBNumber: CB48205339
Molecular Formula: C13H11FN2O3
Formula Weight: 262.24
MOL File: 2359705-88-5.mol

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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property

Boiling point:: 542.9±50.0 °C(Predicted)
Density: 1.461±0.06 g/cm3(Predicted)
form: Solid
pka: 10.63±0.40(Predicted)
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0096964
Product name: Lenalidomide-F
Purity: ≥98.0%
Packaging: 1g
Price: $1586
Updated: 2021/12/16

ChemScene

Product number: CS-0096964
Product name: Lenalidomide-F
Purity: ≥98.0%
Packaging: 5g
Price: $3224
Updated: 2021/12/16

Chemenu

Product number: CM333398
Product name: 2,6-Piperidinedione,3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Purity: 95%+
Packaging: 250mg
Price: $238
Updated: 2021/12/16

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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production

Uses

Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].

IC 50

Cereblon

References

[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974

2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials

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Preparation Products

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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Suppliers

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2359705-88-5, 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-Related Search:

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