3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Product Name: 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
CAS No.: 1061604-41-8
Chemical Name: 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Synonyms: Lenalidomide-4-OH;Lenalidomide Impurity 161;Benzoylchloride,4-chloro-4-fluoro-;3-(4-Hydroxy-1-oxo-isoindolin-2-yl)piperidine-2,6-dione;3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-Hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dionl;3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione;3-(4-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)pi peridine-2,6-dione;2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-;3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione , Lenalidomide-4-OH
CBNumber: CB53079635
Molecular Formula: C13H12N2O4
Formula Weight: 260.24538
MOL File: 1061604-41-8.mol

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3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Property

Boiling point:: 602.9±55.0 °C(Predicted)
Density: 1.498±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.86±0.20(Predicted)
form: Solid
color: White to light brown
InChI: InChI=1S/C13H12N2O4/c16-10-3-1-2-7-8(10)6-15(13(7)19)9-4-5-11(17)14-12(9)18/h1-3,9,16H,4-6H2,(H,14,17,18)
InChIKey: HGPRKOYQOBYISD-UHFFFAOYSA-N
SMILES: N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3O)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0112805
Product name: Lenalidomide-4-OH
Packaging: 5g
Price: $2560
Updated: 2021/12/16

Ambeed

Product number: A983038
Product name: 3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 100mg
Price: $64
Updated: 2021/12/16

aablocks

Product number: AA003AGF
Product name: 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 100mg
Price: $110
Updated: 2021/12/16

aablocks

Product number: AA003AGF
Product name: 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 250mg
Price: $173
Updated: 2021/12/16

Acrotein

Product number: AS01333
Product name: 3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 0.25g
Price: $192.5
Updated: 2021/12/16

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3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Uses

Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

IC 50

Cereblon

References

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Suppliers

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1061604-41-8, 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dioneRelated Search:

2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-methyl- 1-N-Methyl Lenalidomide 3-(4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-1-methyl- 3-(4-Bromophenyl)piperidine-2,6-dione 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- 3-(4-Ethynyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

3-(4-Hydroxy-1-oxo-isoindolin-2-yl)piperidine-2,6-dione

Lenalidomide-4-OH

2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-

3-(4-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)pi peridine-2,6-dione

Benzoylchloride,4-chloro-4-fluoro-

3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

3-(4-Hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dionl

Lenalidomide Impurity 161

3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione , Lenalidomide-4-OH

1061604-41-8