2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Product Name
- 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CAS No.
- 2359705-88-5
- Chemical Name
- 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Synonyms
- Lenalidomide-F;3-(4-Fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CBNumber
- CB48205339
- Molecular Formula
- C13H11FN2O3
- Formula Weight
- 262.24
- MOL File
- 2359705-88-5.mol
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property
- Boiling point:
- 542.9±50.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- form
- Solid
- pka
- 10.63±0.40(Predicted)
- color
- Off-white to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0096964
- Product name
- Lenalidomide-F
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $1586
- Updated
- 2021/12/16
- Product number
- CS-0096964
- Product name
- Lenalidomide-F
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $3224
- Updated
- 2021/12/16
- Product number
- CM333398
- Product name
- 2,6-Piperidinedione,3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Purity
- 95%+
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production
Uses
Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].
IC 50
Cereblon
References
[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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