ChemicalBook > CAS DataBase List > 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Product Name
- 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CAS No.
- 2359705-88-5
- Chemical Name
- 2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Synonyms
- Lenalidomide-F;3-(4-Fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CBNumber
- CB48205339
- Molecular Formula
- C13H11FN2O3
- Formula Weight
- 262.24
- MOL File
- 2359705-88-5.mol
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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property
- Boiling point:
- 542.9±50.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- form
- Solid
- pka
- 10.63±0.40(Predicted)
- color
- Off-white to gray
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0096964
- Product name
- Lenalidomide-F
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $1586
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0096964
- Product name
- Lenalidomide-F
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $3224
- Updated
- 2021/12/16
Chemenu
- Product number
- CM333398
- Product name
- 2,6-Piperidinedione,3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Purity
- 95%+
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
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2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production
Uses
Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].
IC 50
Cereblon
References
[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974
2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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