ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE

Product Name: ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
CAS No.: 34127-22-5
Chemical Name: ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
Synonyms: ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE;3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde;3,6-Dichloropyridazine-4-carboxylic acid ethyl ester;4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester;ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH
CBNumber: CB4836667
Molecular Formula: C7H6Cl2N2O2
Formula Weight: 221.04
MOL File: 34127-22-5.mol

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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Property

Boiling point:: 364.2±37.0 °C(Predicted)
Density: 1.433±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -3.52±0.10(Predicted)
Appearance: Light yellow to brown Solid-Liquid Mixture

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: E940718
Product name: Ethyl3,6-Dichloropyridazine-4-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W020493
Product name: Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging: 5g
Price: $189
Updated: 2021/12/16

ChemScene

Product number: CS-W020493
Product name: Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging: 10g
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0351097
Product name: ETHYL-3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $498.98
Updated: 2021/12/16

AK Scientific

Product number: 4065AB
Product name: Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging: 10g
Price: $523
Updated: 2021/12/16

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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

64-17-5

51149-08-7

34127-22-5

To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in tetrahydrofuran (THF, 150 mL) was sequentially added ethanol (18.15 mL, 311 mmol) and 4-dimethylaminopyridine (DMAP, 0.950 g, 7.77 mmol). 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 16.39 g, 85 mmol) was added in batches over 1 min, and mild exothermic phenomena were observed during the reaction. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and neutralized by adding saturated aqueous sodium bicarbonate (NaHCO3) solution (150 mL). The aqueous phase was extracted with ether (3×250 mL), and the combined organic phases were washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20%→40% ethyl acetate/hexane solution; amount of silica gel: 300 g) to afford ethyl 3,6-dichloro-4-pyridazine-carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.88 (s, 1H), 4.50 (q, J = 7.0 Hz, 2H), 1.46 (t, J = 7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M + H)+, theoretical value 221.0 (C7H7Cl2N2O2)].

References

[1] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 20; 21; 23; 24; 68; 69
[2] Patent: WO2008/130951, 2008, A1. Location in patent: Page/Page column 81
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[4] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/108707, 2004, A1. Location in patent: Page 53-54

ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Suppliers

China 51 India 2 United Kingdom 1 United States 5 Global 59

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Jiangsu Mingchem Corporation

Tel: 0519-85170101
Fax: 0519-85170505
Email: sales@mingchem.com
Country: China
ProdList: 608
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

NanJing Xienuo bio Co.,Ltd.

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Fax: +86-25-84846489
Email: 154301870@qq.com
Country: China
ProdList: 1000
Advantage: 55

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Rlavie Technology Co., Ltd.

Tel: 21-67759270 17717059219
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Country: China
ProdList: 1620
Advantage: 55

Suzhou Nuoouman Biological Technology Co., Ltd.

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Linyi Azelasi Biological Co., Ltd.

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Zhengzhou Ruke Biological Co., Ltd.

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ProdList: 5825
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View Lastest Price from ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 3,6-dichloropyridazine-4-carboxylate 34127-22-5
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-08-07

Shanghai Rlavie Technology Co ltd

Product: 3,6-Dichloropyridazine-4-carboxylic acid ethyl ester 34127-22-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-13

Dideu Industries Group Limited

Product: ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE 34127-22-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-09

34127-22-5, ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATERelated Search:

3,6-Dichloropyridazine-4-carboxylic acid 3,6-Dichloropyridazine 3,6-dichloro-4-pyridazinecarboxaldehyde Methyl 3,6-dichloropyridazine-4-carboxylate SALOR-INT L349488-1EA 3,6-Dichloro-4-methylpyridazine ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Pyridazine-4-carboxylic acid methyl ester 3-Chloro-5-methylpyridazine ETHYL 4-PYRIDAZINECARBOXYLATE

3,6-Dichloropyridazine-4-carboxylic acid ethyl ester

ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE

4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester

ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH

3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde

34127-22-5