ChemicalBook > CAS DataBase List > ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE

ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE

Product Name
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
CAS No.
34127-22-5
Chemical Name
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
Synonyms
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE;3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde;3,6-Dichloropyridazine-4-carboxylic acid ethyl ester;4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester;ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH
CBNumber
CB4836667
Molecular Formula
C7H6Cl2N2O2
Formula Weight
221.04
MOL File
34127-22-5.mol
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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Property

Boiling point:
364.2±37.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
-3.52±0.10(Predicted)
Appearance
Light yellow to brown Solid-Liquid Mixture
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
E940718
Product name
Ethyl3,6-Dichloropyridazine-4-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-W020493
Product name
Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging
1g
Price
$67
Updated
2021/12/16
ChemScene
Product number
CS-W020493
Product name
Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging
5g
Price
$189
Updated
2021/12/16
ChemScene
Product number
CS-W020493
Product name
Ethyl3,6-dichloropyridazine-4-carboxylate
Packaging
10g
Price
$330
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0351097
Product name
ETHYL-3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$498.98
Updated
2021/12/16
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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

64-17-5

51149-08-7

34127-22-5

To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in tetrahydrofuran (THF, 150 mL) was sequentially added ethanol (18.15 mL, 311 mmol) and 4-dimethylaminopyridine (DMAP, 0.950 g, 7.77 mmol). 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 16.39 g, 85 mmol) was added in batches over 1 min, and mild exothermic phenomena were observed during the reaction. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and neutralized by adding saturated aqueous sodium bicarbonate (NaHCO3) solution (150 mL). The aqueous phase was extracted with ether (3×250 mL), and the combined organic phases were washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20%→40% ethyl acetate/hexane solution; amount of silica gel: 300 g) to afford ethyl 3,6-dichloro-4-pyridazine-carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.88 (s, 1H), 4.50 (q, J = 7.0 Hz, 2H), 1.46 (t, J = 7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M + H)+, theoretical value 221.0 (C7H7Cl2N2O2)].

References

[1] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 20; 21; 23; 24; 68; 69
[2] Patent: WO2008/130951, 2008, A1. Location in patent: Page/Page column 81
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[4] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/108707, 2004, A1. Location in patent: Page 53-54

ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl 3,6-dichloropyridazine-4-carboxylate 34127-22-5
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-08-07
Shanghai Rlavie Technology Co ltd
Product
3,6-Dichloropyridazine-4-carboxylic acid ethyl ester 34127-22-5
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
50kgs/month
Release date
2021-11-13
Dideu Industries Group Limited
Product
ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE 34127-22-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-09

34127-22-5, ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATERelated Search:

3,6-Dichloropyridazine-4-carboxylic acid 3,6-Dichloropyridazine 3,6-dichloro-4-pyridazinecarboxaldehyde Methyl 3,6-dichloropyridazine-4-carboxylate SALOR-INT L349488-1EA 3,6-Dichloro-4-methylpyridazine ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE Pyridazine-4-carboxylic acid methyl ester 3-Chloro-5-methylpyridazine ETHYL 4-PYRIDAZINECARBOXYLATE

  • 3,6-Dichloropyridazine-4-carboxylic acid ethyl ester
  • ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
  • 4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester
  • ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH
  • 3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde
  • 34127-22-5