6-Chloro-3-iodo-2-methylpyridine
- Product Name
- 6-Chloro-3-iodo-2-methylpyridine
- CAS No.
- 249291-79-0
- Chemical Name
- 6-Chloro-3-iodo-2-methylpyridine
- Synonyms
- 2-Chloro-5-Iodo-6-Methylpyridne;2-Methyl-3-iodo-6-chloropyridine;2-Chloro-5-iodo-6-methylpyridine;6-CHLORO-3-IODO-2-METHYLPYRIDINE;Pyridine,6-chloro-3-iodo-2-methyl-;6-CHLORO-3-IODO-2-METHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB4838292
- Molecular Formula
- C6H5ClIN
- Formula Weight
- 253.47
- MOL File
- 249291-79-0.mol
6-Chloro-3-iodo-2-methylpyridine Property
- Melting point:
- 30-33°C
- Boiling point:
- 260.4±35.0 °C(Predicted)
- Density
- 1.906±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.04±0.10(Predicted)
- Appearance
- White to yellow Solid
- Sensitive
- Light Sensitive
Safety
- PackingGroup
- III
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- FC55682
- Product name
- 6-Chloro-3-iodo-2-methylpyridine
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- Z0428
- Product name
- 6-Chloro-3-iodo-2-methylpyridine
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- FC55682
- Product name
- 6-Chloro-3-iodo-2-methylpyridine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Z0428
- Product name
- 6-Chloro-3-iodo-2-methylpyridine
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
- Product number
- FC55682
- Product name
- 6-Chloro-3-iodo-2-methylpyridine
- Packaging
- 1g
- Price
- $362.6
- Updated
- 2021/12/16
6-Chloro-3-iodo-2-methylpyridine Chemical Properties,Usage,Production
Uses
6-Chloro-3-iodo-2-methylpyridine is a chlorine- and iodine-substituted pyridine, often used as a pharmaceutical intermediate in drug synthesis and scientific research.
Synthesis
75073-11-9
249291-79-0
General procedure for the synthesis of 2-chloro-5-iodo-6-methylpyridine from 2-amino-5-iodo-6-methylpyridine: 5-iodo-6-methylpyridin-2-ylamine (25 g, 107 mmol, 1 equiv.) was added to a stirred solution of concentrated hydrochloric acid (233 mL) at 0 °C, followed by a slow, dropwise addition of pre-dissolved sodium nitrite (29.5 g, 427 mmol, 4 eq.) solution in water (150 mL). The reaction mixture was stirred at room temperature for 16 hours. After complete consumption of the ingredients, the reaction mixture was cooled to 0 °C and the pH was adjusted to 12 with saturated aqueous sodium hydroxide solution. the reaction mixture was extracted with dichloromethane (3 x 200 mL). The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give a brown oily crude (20 g). The crude was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 4% ethyl acetate as eluent to afford 2-chloro-5-iodo-6-methylpyridine as a brown oil (8 g, 30% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.69 (s, 3H), 6.88 (d, J = 8.04 Hz, 1H), 7.95 (d, J = 8.24 Hz, 1H).LC-MS (m/z): 254.0 (M + H).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 14, p. 2971 - 2973
[2] Patent: WO2014/39484, 2014, A1. Location in patent: Page/Page column 50; 51
6-Chloro-3-iodo-2-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-3-iodo-2-methylpyridine Suppliers
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 025-85760892 13376080562
- Fax
- 025-85766769
- sales@habotech.com
- Country
- China
- ProdList
- 884
- Advantage
- 60
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86(24) 31938773(O)
- Fax
- qq:174941352
- sales@co-chem.com
- Country
- China
- ProdList
- 225
- Advantage
- 62
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
View Lastest Price from 6-Chloro-3-iodo-2-methylpyridine manufacturers
- Product
- 6-CHLORO-3-IODO-2-METHYLPYRIDINE 249291-79-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-31
- Product
- 6-CHLORO-3-IODO-2-METHYLPYRIDINE 649291-79-0
- Price
- US $3.00/KG
- Min. Order
- 1ASSAYS
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2020-03-06
- Product
- 6-CHLORO-3-IODO-2-METHYLPYRIDINE 249291-79-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16