ChemicalBook > CAS DataBase List > 6-Chloro-3-iodo-2-methylpyridine

6-Chloro-3-iodo-2-methylpyridine

Product Name
6-Chloro-3-iodo-2-methylpyridine
CAS No.
249291-79-0
Chemical Name
6-Chloro-3-iodo-2-methylpyridine
Synonyms
2-Chloro-5-Iodo-6-Methylpyridne;2-Methyl-3-iodo-6-chloropyridine;2-Chloro-5-iodo-6-methylpyridine;6-CHLORO-3-IODO-2-METHYLPYRIDINE;Pyridine,6-chloro-3-iodo-2-methyl-;6-CHLORO-3-IODO-2-METHYLPYRIDINE ISO 9001：2015 REACH
CBNumber
CB4838292
Molecular Formula
C6H5ClIN
Formula Weight
253.47
MOL File
249291-79-0.mol
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6-Chloro-3-iodo-2-methylpyridine Property

Melting point:
30-33°C
Boiling point:
260.4±35.0 °C(Predicted)
Density 
1.906±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-1.04±0.10(Predicted)
Appearance
White to yellow Solid
Sensitive 
Light Sensitive
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Safety

PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC55682
Product name
6-Chloro-3-iodo-2-methylpyridine
Packaging
250mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
Z0428
Product name
6-Chloro-3-iodo-2-methylpyridine
Packaging
250mg
Price
$124
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC55682
Product name
6-Chloro-3-iodo-2-methylpyridine
Packaging
500mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
Z0428
Product name
6-Chloro-3-iodo-2-methylpyridine
Packaging
1g
Price
$198
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC55682
Product name
6-Chloro-3-iodo-2-methylpyridine
Packaging
1g
Price
$362.6
Updated
2021/12/16
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6-Chloro-3-iodo-2-methylpyridine Chemical Properties,Usage,Production

Uses

6-Chloro-3-iodo-2-methylpyridine is a chlorine- and iodine-substituted pyridine, often used as a pharmaceutical intermediate in drug synthesis and scientific research.

Synthesis

75073-11-9

249291-79-0

General procedure for the synthesis of 2-chloro-5-iodo-6-methylpyridine from 2-amino-5-iodo-6-methylpyridine: 5-iodo-6-methylpyridin-2-ylamine (25 g, 107 mmol, 1 equiv.) was added to a stirred solution of concentrated hydrochloric acid (233 mL) at 0 °C, followed by a slow, dropwise addition of pre-dissolved sodium nitrite (29.5 g, 427 mmol, 4 eq.) solution in water (150 mL). The reaction mixture was stirred at room temperature for 16 hours. After complete consumption of the ingredients, the reaction mixture was cooled to 0 °C and the pH was adjusted to 12 with saturated aqueous sodium hydroxide solution. the reaction mixture was extracted with dichloromethane (3 x 200 mL). The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give a brown oily crude (20 g). The crude was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 4% ethyl acetate as eluent to afford 2-chloro-5-iodo-6-methylpyridine as a brown oil (8 g, 30% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.69 (s, 3H), 6.88 (d, J = 8.04 Hz, 1H), 7.95 (d, J = 8.24 Hz, 1H).LC-MS (m/z): 254.0 (M + H).

References

[1] Tetrahedron Letters, 2003, vol. 44, # 14, p. 2971 - 2973
[2] Patent: WO2014/39484, 2014, A1. Location in patent: Page/Page column 50; 51

6-Chloro-3-iodo-2-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Chloro-3-iodo-2-methylpyridine manufacturers

Dideu Industries Group Limited
Product
6-CHLORO-3-IODO-2-METHYLPYRIDINE 249291-79-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-31
Career Henan Chemical Co
Product
6-CHLORO-3-IODO-2-METHYLPYRIDINE 649291-79-0
Price
US $3.00/KG
Min. Order
1ASSAYS
Purity
99%min
Supply Ability
500kg
Release date
2020-03-06
Career Henan Chemical Co
Product
6-CHLORO-3-IODO-2-METHYLPYRIDINE 249291-79-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

249291-79-0, 6-Chloro-3-iodo-2-methylpyridineRelated Search:

2-CHLORO-5-IODO-3-METHYLPYRIDINE 2-CHLORO-4-IODO-3-METHYLPYRIDINE 6-CHLORO-3-IODO-2-METHYLPYRIDINE 3-Iodo-2-methylpyridine 2-Chloro-5-iodopyridine

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  • Pyridines
  • Heterocyclic Compounds