6-chloro-2-methyl-2H-indazol-5-amine
- Product Name
- 6-chloro-2-methyl-2H-indazol-5-amine
- CAS No.
- 1893125-36-4
- Chemical Name
- 6-chloro-2-methyl-2H-indazol-5-amine
- Synonyms
- Ensitrelvir Intermediate;2H-Indazol-5-amine, 6-chloro-2-methyl-;S-217622-001;6-chloro-2-methyl-indazol-5-amine;6-gas-2-methyl-21-inch call-5-blad;6-chloro-2-methyl-2H-indazol-5-amine;5-Amino-6-chloro-2-methyl-2H-indazole;6-Chloro-2-methyl-2H-indazol-5-ylamine;Atracurium Impurity 61 (Atracurium Besilate EP Impurity D)
- CBNumber
- CB48392288
- Molecular Formula
- C8H8ClN3
- Formula Weight
- 181.62
- MOL File
- 1893125-36-4.mol
6-chloro-2-methyl-2H-indazol-5-amine Property
- Boiling point:
- 365.6±22.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- pka
- 2.05±0.10(Predicted)
- InChI
- InChI=1S/C8H8ClN3/c1-12-4-5-2-7(10)6(9)3-8(5)11-12/h2-4H,10H2,1H3
- InChIKey
- YRZNRFJEBAPCCO-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(N)C(Cl)=C2)=CN1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
6-chloro-2-methyl-2H-indazol-5-amine Chemical Properties,Usage,Production
Synthesis
A suspension of 6-Chloro-1-methyl-5-nitro-1H-indazole (700 mg, 3.31 mmol), NH4CI (1 .59g, 29.77mmol) & Fe powder (1.66g, 29.77mmol) in a mixture of EtOH: Water (15mL: 15mL) was heated to 80°C for 6h. After 6h, TLC analysis indicated the formation of a polar spot (Ninhydrin positive). Then, the reaction mixture was cooled to RT and filtered through the celite bed; the celite bed was washed with EtOH (50mL); the filtrate was concentrated under reduced pressure to give a crude product. The crude product was purified by column chromatography (silica gel 100-200mesh) using 25% EtOAc in petroleum ether as an eluent to give 6- chloro-2-methyl-2H-indazol-5-amine (quantitative yield) as an off-white solid.
6-chloro-2-methyl-2H-indazol-5-amine Preparation Products And Raw materials
Raw materials
Preparation Products
6-chloro-2-methyl-2H-indazol-5-amine Suppliers
- Tel
- +86-13917743231
- sales@rrscientific.com
- Country
- United States
- ProdList
- 878
- Advantage
- 58
View Lastest Price from 6-chloro-2-methyl-2H-indazol-5-amine manufacturers
- Product
- 6-chloro-2-methyl-2H-Indazol-5-amine 1893125-36-4
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-10-20
- Product
- 6-chloro-2-methyl-2H-indazol-5-amine 1893125-36-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2023-09-15
- Product
- 6-chloro-2-methyl-2H-indazol-5-amine 1893125-36-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2023-09-15