TERT-BUTYL 4-CYANOBENZYLCARBAMATE
- Product Name
- TERT-BUTYL 4-CYANOBENZYLCARBAMATE
- CAS No.
- 66389-80-8
- Chemical Name
- TERT-BUTYL 4-CYANOBENZYLCARBAMATE
- Synonyms
- N-Boc-4-cyanobenzylamine;4-BOC-AMINOMETHYL-BENZONITRILE;TERT-BUTYL 4-CYANOBENZYLCARBAMATE;tert-butyl N-[(4-cyanophenyl)methyl]carbamate;Carbamic acid, N-[(4-cyanophenyl)methyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB4841968
- Molecular Formula
- C13H16N2O2
- Formula Weight
- 232.28
- MOL File
- 66389-80-8.mol
TERT-BUTYL 4-CYANOBENZYLCARBAMATE Property
- Melting point:
- 90-92 °C
- Boiling point:
- 392.9±35.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.91±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB140510
- Product name
- tert-Butyl 4-cyanobenzylcarbamate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 7357AJ
- Product name
- tert-Butyl4-cyanobenzylcarbamate
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- FB140510
- Product name
- tert-Butyl 4-cyanobenzylcarbamate
- Packaging
- 5G
- Price
- $260
- Updated
- 2021/12/16
- Product number
- AS29620
- Product name
- 4-(Boc-aminomethyl)benzonitrile
- Purity
- 95+%
- Packaging
- 5G
- Price
- $354
- Updated
- 2021/12/16
- Product number
- FB140510
- Product name
- tert-Butyl 4-cyanobenzylcarbamate
- Packaging
- 10g
- Price
- $452.5
- Updated
- 2021/12/16
TERT-BUTYL 4-CYANOBENZYLCARBAMATE Chemical Properties,Usage,Production
Synthesis
24424-99-5
15996-76-6
66389-80-8
(1) To a solution of 4-(aminomethyl)benzonitrile hydrochloride (5.00 g, 29.7 mmol) in dichloromethane (167 mL) at 0 °C was added sodium carbonate (7.54 g, 71.2 mmol). Subsequently, di-tert-butyl dicarbonate (7.57 mL, 32.6 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, water was added to terminate the reaction and the product was extracted with ethyl acetate. The organic layer was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by silica gel (NH) column chromatography (eluent: n-hexane/ethyl acetate=1:1) to give tert-butyl 4-cyanobenzylcarbamate (6.48 g, 94% yield).
References
[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 18, p. 4431 - 4434
[2] Chemistry - A European Journal, 2018, vol. 24, # 68, p. 18075 - 18081
[3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1552; 1553; 1554
[4] Journal of the American Chemical Society, 2012, vol. 134, # 25, p. 10317 - 10320
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 528 - 533
TERT-BUTYL 4-CYANOBENZYLCARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 4-CYANOBENZYLCARBAMATE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from TERT-BUTYL 4-CYANOBENZYLCARBAMATE manufacturers
- Product
- TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8
- Price
- US $60.00-360.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-10
- Product
- TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8
- Price
- US $55.00-700.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-12
- Product
- TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06