ETHYL 4-BROMO-3-HYDROXYBENZOATE
- Product Name
- ETHYL 4-BROMO-3-HYDROXYBENZOATE
- CAS No.
- 33141-66-1
- Chemical Name
- ETHYL 4-BROMO-3-HYDROXYBENZOATE
- Synonyms
- ETHYL 4-BROMO-3-HYDROXYBENZOATE;Benzoic acid, 4-bromo-3-hydroxy-, ethyl ester
- CBNumber
- CB4842152
- Molecular Formula
- C9H9BrO3
- Formula Weight
- 245.07
- MOL File
- 33141-66-1.mol
ETHYL 4-BROMO-3-HYDROXYBENZOATE Property
- Melting point:
- 90-92 °C
- Boiling point:
- 329.9±22.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 7.66±0.10(Predicted)
- color
- White
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0046874
- Product name
- Ethyl4-bromo-3-hydroxybenzoate
- Packaging
- 5g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- OR949729
- Product name
- Ethyl4-bromo-3-hydroxybenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $221
- Updated
- 2021/12/16
- Product number
- HCH0351103
- Product name
- ETHYL-4-BROMO-3-HYDROXYBENZOATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $257.25
- Updated
- 2021/12/16
- Product number
- OR949729
- Product name
- Ethyl4-bromo-3-hydroxybenzoate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
- Product number
- OR949729
- Product name
- Ethyl4-bromo-3-hydroxybenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
ETHYL 4-BROMO-3-HYDROXYBENZOATE Chemical Properties,Usage,Production
Synthesis
14348-38-0
33141-66-1
General procedure for the synthesis of ethyl 4-bromo-3-hydroxybenzoate from 4-bromo-3-hydroxybenzoic acid: 4-bromo-3-hydroxybenzoic acid (5.0 g, 0.023 mol) was dissolved in a solvent mixture of 150 mL of benzene and 5 mL of ethanol, and 1 mL of methanesulfonic acid (MeSO3H) was added as a catalyst. A Dean-Stark manifold was installed and the reaction mixture was heated to reflux for 10 hours to remove the water generated. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane (CH2Cl2) and washed sequentially with water, 5% sodium bicarbonate (NaHCO3) solution and saturated brine. The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane) to afford the target product ethyl 4-bromo-3-hydroxybenzoate (5.1 g, 90% yield) as a white solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ1.39 (t, J=7.2 Hz, 3H), 4.37 (q, J=7.2 Hz, 2H), 5.75 (s, 1H), 7.48 (d, J=8.1 Hz, 1H), 7.55 (d, J=8.1 Hz, 1H), 7.68 (s, 1H).
References
[1] Patent: US2003/176506, 2003, A1
ETHYL 4-BROMO-3-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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