ChemicalBook > CAS DataBase List > (4R)-4-Methyl-2-oxazolidinone

(4R)-4-Methyl-2-oxazolidinone

Product Name
(4R)-4-Methyl-2-oxazolidinone
CAS No.
4042-43-7
Chemical Name
(4R)-4-Methyl-2-oxazolidinone
Synonyms
(4R)-4-Methyl-2-oxazolidinone;2-Oxazolidinone,4-methyl-,(4S)-;2-Oxazolidinone, 4-methyl-, (4R)-;(4R)-4-Methyl-2-oxazolidinone4042-43-7;Benzenepropanoicacid,6-chloro-β-oxo-,methylester
CBNumber
CB4853602
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
4042-43-7.mol
More
Less

(4R)-4-Methyl-2-oxazolidinone Property

Melting point:
45.9 °C
Boiling point:
302.6±9.0 °C(Predicted)
Density 
1.095±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.84±0.40(Predicted)
Appearance
White to light yellow Solid
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
M336368
Product name
(R)-4-Methyloxazolidin-2-one
Packaging
50mg
Price
$65
Updated
2021/12/16
Activate Scientific
Product number
AS90120
Product name
(R)-4-Methyloxazolidin-2-one
Purity
95+% ee
Packaging
250mg
Price
$122
Updated
2021/12/16
AK Scientific
Product number
5441AB
Product name
(R)-4-Methyloxazolidin-2-one
Packaging
250mg
Price
$131
Updated
2021/12/16
Apolloscientific
Product number
OR938550
Product name
(R)-4-Methyloxazolidin-2-one
Purity
95%
Packaging
250mg
Price
$225
Updated
2021/12/16
Activate Scientific
Product number
AS90120
Product name
(R)-4-Methyloxazolidin-2-one
Purity
95+% ee
Packaging
1g
Price
$281
Updated
2021/12/16
More
Less

(4R)-4-Methyl-2-oxazolidinone Chemical Properties,Usage,Production

Synthesis

75-44-5

35320-23-1

4042-43-7

D-alaninol (8.65 g, 0.12 mmol) was dissolved in a mixed solvent of toluene and KOH aqueous solution (124 mL, 12.5% aqueous solution, 0.28 mmol) at 0 °C. Phosgene (72.7 mL, 20% toluene solution, 0.14 mmol) was added slowly dropwise, and the dropwise acceleration was controlled to maintain the internal temperature of the reaction system below 5 °C. After the dropwise addition, the reaction was continued to be stirred at 0 °C for 40 min. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The crude product was dissolved with industrial methanol, filtered to remove insoluble matter, and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel fast column chromatography (eluent gradient: 40-100% cyclohexane solution of ethyl acetate), and 10.4 g (90% yield) of (R)-4-methyl-2-oxazolidinone was finally obtained as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.00 (broad single peak, 1H), 4.50 (triple peak, J=6.5 Hz, 1H), 4.07-3.97 (multiple peaks, 1H), 3.95 (double dichotomous peaks, J=7.8,6.2 Hz, 1H), and 1.30 (dichotomous peak, J=6.1 Hz, 3H).

References

[1] Patent: WO2017/1645, 2017, A1. Location in patent: Page/Page column 78; 79
[2] Patent: US2017/2022, 2017, A1. Location in patent: Paragraph 0185-0186

(4R)-4-Methyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(4R)-4-Methyl-2-oxazolidinone Suppliers

China 47 India 2 United States 5 Global 54
Shijizhuang Zhoukun Pharmaceutical Technology Co., LTD
Tel
0311-83784138 18633934202
Email
zhoukunpharma@163.com
Country
China
ProdList
2125
Advantage
58
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Doly Chemical CO.,LTD.
Tel
021-34716221 15800796336
Fax
+86-21-31329566
Email
sales@dolypharm.com
Country
China
ProdList
289
Advantage
55
Shanghai Apichemical CO.,LTD
Tel
021-51370612;
Fax
(86)21-58561183
Email
info@apichemical.com
Country
China
ProdList
242
Advantage
60
Shanghai Leto Pharmatech Co.,Ltd.
Tel
18016401466
Fax
QQ: 1375988926
Email
sales@letopharm.com
Country
China
ProdList
245
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Zhengzhou Guancheng Laboratory equipment Sales
Tel
0371-88888888 272369594
Fax
QQ:272369594
Email
2723695949@qq.com
Country
China
ProdList
4955
Advantage
50
DebyeTec.com Inc.
Tel
18-086626237 18086626237
Fax
qq:2693528373
Email
2693528373@qq.com
Country
China
ProdList
2973
Advantage
56
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Blocksynth Pharmaceutical Technology Co.,Ltd
Tel
0086-19817745290; +8619817745290
Email
bd@blocksynth.com
Country
China
ProdList
5661
Advantage
58
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3609
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Shanghai Amico Chemicals Co. LTD
Tel
微信 17321281695 18019252918
Fax
qq:1454668768
Email
1454668768@qq.com
Country
China
ProdList
14873
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
Shenyang Maud Pharmaceutical Technology Co., Ltd.
Tel
024-23982345
Email
1020788318@qq.com
Country
China
ProdList
2251
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81139210 +86-18192627656
Fax
+86-29-88380327
Email
1059@dideu.com
Country
China
ProdList
3588
Advantage
58
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7327
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
11438
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Shanghai Lingfu Pharmaceutical Research Co. LTD
Tel
+86(21)5895 0110 19945755304
Email
sales@chemany.com
Country
China
ProdList
9984
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50751
Advantage
58
Ningbo Zhenyue Pharmaceutical Technology Co., Ltd
Tel
19817745290
Email
bd@blocksynth.com
Country
China
ProdList
5870
Advantage
58
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863 18108198598
Fax
028-85632863
Email
micxysales@163.com
Country
China
ProdList
10475
Advantage
58
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281
Email
1522334715@qq.com
Country
China
ProdList
7507
Advantage
58
Xi'an Chengyuan Pharmaceutical Technology Co., Ltd
Tel
17792872120
Email
3665789492@qq.com
Country
China
ProdList
476
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
14580
Advantage
58
GUANGZHOU AANPHARM TECHNOLOGY CO.,LTD
Tel
020-86211473 13925088720
Email
linda@aanpharm.com
Country
China
ProdList
2944
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Shenzhen Nexconn Pharmatechs Ltd
Tel
+86-755-89396905 +86-15013857715
Email
admin@nexconn.com
Country
China
ProdList
10405
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Shanghai Shize Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shizezjp@163.com
Country
CHINA
ProdList
6174
Advantage
58
Shanghai Qincheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shqcsw01@163.com
Country
CHINA
ProdList
6821
Advantage
58
Rhenbo (Shanghai) Biochemical Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6333
Advantage
58
Shanghai Jingke Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
jingkehuaxue@163.com
Country
CHINA
ProdList
6141
Advantage
58
Shanghai Caiyou Industrial Co., Ltd.
Tel
--
Fax
--
Email
15821073967@163.com
Country
CHINA
ProdList
6748
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Shanghai Wowu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shhebio@126.com
Country
CHINA
ProdList
6137
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Xiamen Flint Chemical Co., Ltd
Tel
--
Fax
--
Email
sales@flintchem.com
Country
China
ProdList
6589
Advantage
65
More
Less

View Lastest Price from (4R)-4-Methyl-2-oxazolidinone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(4R)-4-Methyl-2-oxazolidinone 4042-43-7
Price
US $3.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-29

4042-43-7, (4R)-4-Methyl-2-oxazolidinoneRelated Search:

(R)-(-)-3-PROPIONYL-4-ISOPROPYL-2-OXAZOLIDINONE (-)-CHIRACAMPHOX (N-CHLOROACETYL)-(4S)-BENZYL-2-OXAZOLIDINONE (R)-(-)-4-Phenyl-2-oxazolidinone (R)-(+)-4-Isopropyl-2-oxazolidinone (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (R)-4-Benzyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE N-PROPIONYL-(4S,5R)-4-METHYL- 5-PHENYL-2-OXAZOLIDINONE N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE (R)-(-)-5,5-DIMETHYL-4-PHENYL-2-OXAZOLIDINONE N-ACETYL-(4S,5R)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE N-CROTONYL-(4R,5S)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE Z-D-Phenylalanine N-carboxyanhydride (R)-(+)-4-BENZYL-5,5-DIMETHYL-2-OXAZOLIDINONE 3-BROMO-4,4-DIMETHYL-2-OXAZOLIDINONE N-(DIETHYLPHOSPHONOACETYL) (4R)-BENZYL-2-OXAZOLIDINONE

  • (4R)-4-Methyl-2-oxazolidinone
  • (4R)-4-Methyl-2-oxazolidinone4042-43-7
  • 2-Oxazolidinone, 4-methyl-, (4R)-
  • 2-Oxazolidinone,4-methyl-,(4S)-
  • Benzenepropanoicacid,6-chloro-β-oxo-,methylester
  • 4042-43-7