Alizarin

ChemicalBook > CAS DataBase List > Alizarin

Product Name: Alizarin
CAS No.: 72-48-0
Chemical Name: Alizarin
Synonyms: Alizarin Red;SULFATED CASTOR OIL;1,2-DIHYDROXYANTHRAQUINONE;CI 58000;Alizarine;Aliazrin;Alizarine Red;TURKEY RED OIL;MORDANT RED 11;C.I. Pigment Red 83
CBNumber: CB4854164
Molecular Formula: C14H8O4
Formula Weight: 240.21
MOL File: 72-48-0.mol

Less

Alizarin Property

Melting point:: 287 °C
Boiling point:: 430 °C
Density: 1.06 g/mL at 20 °C
refractive index: 1.5190 (estimate)
Flash point:: 430°C subl.
storage temp.: Inert atmosphere,Room Temperature
solubility: Solubility Virtually insoluble in water; moderately soluble in ethanol, soluble in benzene, toluene, Ixylene, pyridine, acetic acid
form: Fine Powder
Colour Index: 58000
pka: 6.77(at 25℃)
color: Orange to orange-brown
PH: 5.5～7.2
PH Range: Yellow (5.5) to red (6.8);Red (10.1) to purple (12.1)
Water Solubility: Soluble in hexane and chloroform. Slightly soluble in water.
λmax: 567nm, 609nm
ε(extinction coefficient): 13000 at 227-233nm in 0.1 M NaOH at 0.01g/L
26000 at 268-274nm in 0.1 M NaOH at 0.01g/L
Merck: 14,251
BRN: 1914037
Stability:: Stable. Incompatible with strong oxidizing agents, strong bases.
Biological Applications: Detecting microorganisms; treating dermatological conditions
Major Application: Plasma displays, Antireflective coatings, chemical-mechanical polishing, photoreceptors, glass coatings, paints, anticorrosion coatings, thermoplastics, wood coloring, textiles, pH sensor device, detergent, hair dyes, darkening skin, cosmetics, parasiticide, antifungal agent
InChIKey: RGCKGOZRHPZPFP-UHFFFAOYSA-N
LogP: 2.479 (est)
CAS DataBase Reference: 72-48-0(CAS DataBase Reference)
NIST Chemistry Reference: Alizarin(72-48-0)
EPA Substance Registry System: Alizarin (72-48-0)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/38-36/37/38
Safety Statements: 26-36-24/25-22
WGK Germany: 3
RTECS: YO8300000
TSCA: Yes
HS Code: 29146990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 122777
Product name: Alizarin
Purity: Dye content 97%
Packaging: 100g
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: 122777
Product name: Alizarin
Purity: Dye content 97%
Packaging: 500g
Price: $722
Updated: 2024/03/01

TCI Chemical

Product number: D0242
Product name: Alizarin
Purity: >95.0%(HPLC)
Packaging: 25g
Price: $33
Updated: 2024/03/01

Alfa Aesar

Product number: A14404
Product name: Alizarin, 94%
Packaging: 100g
Price: $55.6
Updated: 2024/03/01

Alfa Aesar

Product number: A14404
Product name: Alizarin, 94%
Packaging: 500g
Price: $219
Updated: 2024/03/01

Less

Alizarin Chemical Properties,Usage,Production

Chemical Properties

orange-red crystals or powder

History

In ancient times, alizarin was the preferred red dye. Cloth dyed with it has been found in Egyptian tombs dating 6000 years ago. The dye is found in the madder plant, a member of the Rubiaceae family. In 1944 about 35 species of this plant were known, but the use of more sophisticated analytical methods led to the detection of many more species; by 1984 the number had increased to 50. Alizarin is a mordant dye forming various colored coordination complexes with different metallic salts.

Uses

antimutagen

Uses

Alizarin has a major application in the manufacture of the madder lake pigments which is commonly called as Rose madder and Alizarin crimson. It is involved in the studies of bone growth, osteoporosis, bone marrow and calcium deposits in the vascular system. It is also used as a stain in calcite and aragonite to identify calcium carbonate, and synovial fluid to asses for basic calcium phosphate crystals. It is used in colorimetric measurements for quantification of amine extraction by model food simulants from epoxy polymer.

Uses

Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by ce lls of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit prolife ration, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis.

Definition

ChEBI: A dihydroxyanthraquinone that is anthracene-9,10-dione in which the two hydroxy groups are located at positions 1 and 2.

Preparation

(a) 2 – Bromoanthraquinone and Potassium hydroxide heating; (b) 9,10-Dioxo-9,10-dihydroanthracene-2-sulfonic acid (Sodium) and Sodium hydroxide and Sodium nitrate and Sodium chlorate heating; (C) Anthracene-9,10-dione?and Sodium hydroxide and Sodium chlorate and Sodium nitrate heating (GP 186526); (d) in the presence of Sodium nitrite and Sodium hydroxide and Anthracene-9,10-dione?and Sodium nitrate heating (GP 241806245 987); (e) in the Oxidant and Sodium sulfite and the presence of lime, anthracene in a nitrocellulose derivatives and Sodium hydroxide heating (GP 292247); (f) 2 – Anthraquinonesulfonic acid in the presence of air, with the Sodium hydroxide Etanol wetting treatment (GP 287270); (g) 2-Chloroanthracene-9,10-dione Sodium chlorate in the presence of alkali fusion for (USP 1744815); (h) 2-Methylanthracene-9,10-dione in the presence of Oxidant, with Sodium hydroxide treatment (BP 293328).

Definition

An important orange-red organic compound used in the dyestuffs industry to produce red lakes. It occurs naturally in the root of the plant madder and may also be synthesized from anthraquinone.

Definition

alizarin: An orange-red compound,C₁₄H₈O₄. The compound is a derivativeof anthraquinone, with hydroxylgroups substituted at the 1and 2 positions. It is an importantdyestuff producing red or violetlakes with metal hydroxide.Alizarin occurs naturally as the glucosidein madder. It can be synthesizedby heating anthraquinone withsodium hydroxide.

Biological Activity

alizarin is an anthraquinone dye for detecting the presence of calcium salts [1].alizarin belongs to the anthraquinone group. it is a chelator for calcium and is commonly used to stain the calcifying or calcio-receptive zone of the collagenous matrix where calcium salts are being deposited. on the other hand, the alizarin complexone is used for bone staining in vivo to study bone remodeling [1].alizarin is proved to have anti-tumor efficacy. it suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro. among these, the osteosarcoma cells appear to be most sensitive. the ic50 values of alizarin against three osteosarcoma cell lines saos-2, mg-63 and u-2 os are 27.5, 29 and 69.9μg/ml, respectively. alizarin inhibits the cell growth through cell proliferation blockade rather than induction of apoptosis. it inhibits the phosphorylation of erk. in addition, alizarin is also found to induce s-phase arrest as well as a decrease of the g0/g1 and g2/m phases [1].

Synthesis

1,2-Dihydroxyanthraquinone is prepared from anthraquinone by alkali melt or from anthraquinone-2-sulfonic acid with 50 % aqueous sodium hydroxide and sodium nitrate at 190 – 200 ?C .

Properties and Applications

commonly known as 1,2-Dihydroxyanthracene-9,10-dione , calcium, aluminum mordanting for red to blue light red, chromium for dark blue light red, iron as dark purplish red. Claybank powder. Slightly soluble in water, but soluble in Methanol, Acetone Etanol, boiling, alkali and Cellosolve, slightly soluble in benzene, Carbon tetrachloride, insoluble in cold Etanol, Stout solvent, soluble in alkali liquor for royal purple. In concentrated sulfuric acid for yellow red, red yellow after diluted produce precipitation; In the Sodium hydroxide to purple. Used for wool fabric dyeing and used as organic pigment.

Standard	Ironing Fastness	Light Fastness	Fulling		Persperation Fastness	Soaping	Water
Standard	Ironing Fastness	Light Fastness	Alkali	Acid	Persperation Fastness	Soaping	Water
ISO	3-4	7	3-4	1	3	4	4
AATCC	Dry 2,wet 5	7	2-3		4	4	5

Purification Methods

Alizarin crystallises from glacial acetic acid or 95% EtOH. It can also be sublimed at 110o/2mm. It is an indicator with max at 452nm (pH 5.8) and 520nm (pH 7.2). [Beilstein 8 IV 3256.]

References

[1] fotia c, avnet s, granchi d, baldini n. the natural compound alizarin as an osteotropic drug for the treatment of bone tumors. j orthop res. 2012 sep;30(9):1486-92.

Alizarin Preparation Products And Raw materials

Raw materials

Sodium anthraquinone-2-sulfonate 2-Anthraquinonesulfonic acid Anthraquinone Potassium chlorate Sodium hydroxide Potassium nitrate

Preparation Products

Alizarin Complexone

Less

Alizarin Suppliers

Americas 1 Australia 1 Austria 1 Belgium 1 Canada 2 China 317 Czech 1 Czech Republic 1 Europe 5 France 4 Germany 5 Hungary 1 India 36 Japan 5 Poland 1 Russia 1 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 17 United States 62 Global 469

JiangSu Star Science Co.,Ltd

Tel: 400-400-605-7200-7200 15366279656
Email: sales040@b2star.com
Country: China
ProdList: 3761
Advantage: 58

Shandong Haizhou Biological Engineering Co. LTD

Tel: 130-0567-0367 13006570367
Email: 3429531746@qq.com
Country: China
ProdList: 2456
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9371
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44733
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8590
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2859
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4728
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 1316706386
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-84699383-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 971
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2851037746@qq.com
Country: China
ProdList: 1104
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2045
Advantage: 56

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653713
Email: xingui2022@126.com
Country: China
ProdList: 10003
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11733
Advantage: 59

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16684
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 13096311329 028-88469284 616445927
Fax: 028-88469284
Email: 616445927@qq.com
Country: China
ProdList: 2874
Advantage: 50

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Less

View Lastest Price from Alizarin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Alizarin 72-48-0
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-12-05

Shanghai Standard Technology Co., Ltd.

Product: Alizarin 72-48-0
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-05-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: Alizarin 72-48-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

72-48-0, AlizarinRelated Search:

Alizarin Alizarin Complexone Carmine CARMINE 1,2,5,8-TETRAHYDROXYANTHRAQUINONE ANTHRACENE BROWN Alizarin Red S PURPURIN ANTHRAPURPURIN Carminic Acid ALIZARIN BLUE S 1,4-Dihydroxyanthraquinone-2-sulfonic acid 1,8-Dihydroxyanthraquinone 1,4-dihydroxy-9,10-anthracenedione CASTOR OIL, SULFONATED 1,5-Dihydroxy-9,10-anthracenedione 1,8-Diamino-4,5-dihydroxy-9,10-anthracenedion Solvent Green 28

alizarinb

Alizarine

Alizarine 3B

Alizarine B

Alizarine Indicator

Alizarine L Paste

Alizarine Lake Red 2P

Alizarine Lake Red 3P

Alizarine Lake Red IPX

Alizarine NAC

Alizarine Paste 20 percent Bluish

Alizarine paste 20% bluish

Alizarine Red

1,2-Dihydroxy-anthrachinon

1,2-dihydroxy-anthraquinon

Alizarin,1,2-Dihydroxyanthraquinone, Mordant Red 11

ALIZARIN SOLUTION 0.1% in Methanol

Anthraquinonic

Alizarin, pure, 97% 100GR

Alizarin, pure, 97% 25GR

Alizarine Red B

Alizarine Red B2

Alizarine Red IP

Alizarine Red IPP

Alizarine Red L

dandcorangeno.15

Deep Crimson Madder 10821

Deep Crimson Madder 10821E

deepcrimsonmadder10821

Eljon Madder

Eljon Madder M

eljonmadder

Mitsui Alizarine B

Mitsui Alizarine BS

mitsuializarineb

Pincoffin

Sanyo Carmine L2B

Sanyo Carmine l2BT

sanyocarminel2b

sodiumsulforicinoleate

Turkey Red

ALIZARINPRIMVEROSIDE

1,2-Dihydroxyanthraqhinone

Mordant red 11 (C.I. 58000)

Alizarin Red

1,2-Dihydroxyanthraquinone, Mordant Red 11

1,2-Anthraquinonediol

1,2-dihydroxy-10-anthracenedione

1,2-Dihydroxy-9,10-anthraquinone

1,2-Dihydroxyanthra-9,10-quinone

1,2-Dihydroxyanthrachinon

Alizarin, 97%, pure

Alizarine Red YP

D&C Orange No.15

10-Anthracenedione,1,2-dihydroxy-9

9,10-Anthracenedione, 1,2-dihydroxy-

9,10-Anthracenedione,1,2-dihydroxy-

Ailzarin(c.1.No.5800)