5-Hydroxy-1H-imidazole-4-carboxamide
- Product Name
- 5-Hydroxy-1H-imidazole-4-carboxamide
- CAS No.
- 56973-26-3
- Chemical Name
- 5-Hydroxy-1H-imidazole-4-carboxamide
- Synonyms
- AHM;Ampba;SL-1207;SM 108);Bredinin aglycone;FF-10501-01 (FF-10501;SM-108【antitumor agent】;4-Carbamoylimidazolium-5-olate;4-carbamoyl-5-hydroxyimidazole;5-hydroxyimidazole-4-carboxamide
- CBNumber
- CB4855000
- Molecular Formula
- C4H5N3O2
- Formula Weight
- 127.1
- MOL File
- 56973-26-3.mol
5-Hydroxy-1H-imidazole-4-carboxamide Property
- Melting point:
- 260°C
- Boiling point:
- 575.0±35.0 °C(Predicted)
- Density
- 1.627
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Solid
- pka
- 7.20±0.15(Predicted)
- color
- Grey
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H943250
- Product name
- 5-Hydroxy-3H-imidazole-4-carboxamide
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H943250
- Product name
- 5-Hydroxy-3H-imidazole-4-carboxamide
- Packaging
- 5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- Q084
- Product name
- 5-Hydroxy-1H-imidazole-4-carboxamide
- Packaging
- 250mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- CHM0012710
- Product name
- 5-HYDROXY-3H-IMIDAZOLE-4-CARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- 10825
- Product name
- 5-Hydroxy-3H-imidazole-4-carboxamide
- Packaging
- 500mg
- Price
- $890
- Updated
- 2021/12/16
5-Hydroxy-1H-imidazole-4-carboxamide Chemical Properties,Usage,Production
Chemical Properties
Grey Solid
Uses
5-Hydroxy-3H-imidazole-4-carboxamide (cas# 56973-26-3) is a compound useful in organic synthesis.
Definition
ChEBI: A hydroxyimidazole that is 5-hydroxyimidazole in which the hydrogen at position 4 is replaced by an aminocarbonyl group.
Synthesis
66934-73-4
56973-26-3
Under nitrogen protection, 20.0 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloride dihydrate prepared according to the method of Reference Example 2 was dissolved in 240 mL of a 0.45 mol/L hydrochloric acid solution, and heated to 50°C to dissolve it completely. Maintaining the reaction temperature at 50 °C, 40 mL of an aqueous solution containing 14.3 g of sodium formate was added slowly and dropwise over 35 minutes. Upon completion of the reaction, the reaction mixture was cooled to an internal temperature of 5 °C and stirring was continued for 90 minutes. The resulting crystals were collected by filtration, and the crystals were washed sequentially using a mixture comprising 20 mL of acetone and 40 mL of water and 60 mL of acetone, resulting in 12.6 g of 5-hydroxy-1H-imidazole-4-carboxamide-3/4 hydrate, the product being a pale yellow crystal. The water content of the product was 8.6% (determined by Karl Fischer method). Infrared spectra (ATR method) showed characteristic absorption peaks located at 1655, 1619, 1584, 1551 cm?1. Powder X-ray diffraction pattern and infrared absorption spectra (ATR method) are demonstrated in Fig. 8, Table 3 and Fig. 9, respectively.
References
[1] Patent: EP2762469, 2014, A1. Location in patent: Paragraph 0144-0145
[2] Patent: US2015/51408, 2015, A1. Location in patent: Paragraph 0039
5-Hydroxy-1H-imidazole-4-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Hydroxy-1H-imidazole-4-carboxamide manufacturers
- Product
- 5-Hydroxy-1H-imidazole-4-carboxamide 56973-26-3
- Price
- US $31.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99
- Supply Ability
- 10t
- Release date
- 2020-05-18