ChemicalBook > CAS DataBase List > Moxidectin

Moxidectin

Product Name
Moxidectin
CAS No.
113507-06-5
Chemical Name
Moxidectin
Synonyms
Moxidectin CRS;milbemycin B;Quest;Equest;proheart;Moxdectin;Moxicitin;ProHeart 6;Moxidectin;Moxibustin
CBNumber
CB4874771
Molecular Formula
C37 H53 N O8
Formula Weight
639.82
MOL File
113507-06-5.mol
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Moxidectin Property

Melting point:
132 °C
Boiling point:
790.0±70.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥128 mg/mL in EtOH; ≥129.4 mg/mL in DMSO; ≥3.27 mg/mL in H2O with gentle warming and ultrasonic
pka
12.46±0.70(Predicted)
color 
White to Almost white
Stability:
Light Sensitive
InChIKey
YZBLFMPOMVTDJY-LSGXYNIPSA-N
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Safety

Hazard Codes 
T,N
Risk Statements 
25-50
Safety Statements 
45-61-24/25
RIDADR 
2588
WGK Germany 
3
RTECS 
PY5438800
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33746
Product name
Moxidectin
Purity
VETRANAL
Packaging
25mg
Price
$204
Updated
2024/03/01
Sigma-Aldrich
Product number
1448559
Product name
Moxidectin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$678
Updated
2024/03/01
TCI Chemical
Product number
M3136
Product name
Moxidectin
Packaging
250MG
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
M3136
Product name
Moxidectin
Packaging
1G
Price
$320
Updated
2024/03/01
Cayman Chemical
Product number
17165
Product name
Moxidectin
Purity
≥90%
Packaging
5mg
Price
$37
Updated
2024/03/01
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Moxidectin Chemical Properties,Usage,Production

Description

Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin. It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively. Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM. Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

Uses

anthelmintic, antiparasitic

Uses

Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is is fou nd in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.

Uses

Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin. Moxidectin binds selectively to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Definition

ChEBI: Moxidectin is a milbemycin.

Veterinary Drugs and Treatments

In dogs and cats, moxidectin with lufenuron is indicated as a once a month topical preventative for the prevention of heartworm, flea adulticide, ear mites (cats) and treatment for hookworms, roundworms, and whipworms (dogs). It has also been successfully used as a treatment for generalized demodicosis.
In cattle, moxidectin is indicated for the treatment and control of the following internal [adult and fourth stage larvae (L4)] and external parasites: Gastrointestinal roundworms: Ostertagia ostertagi (adult and L4, including inhibited larvae), Haemonchus placei (adult), Trichostrongylus axei (adult and L4), Trichostrongylus colubriformis (adult), Cooperia oncophora (adult), Cooperia punctata (adult), Bunostomum phlebotomum (adult), Oesophagostomum radiatum (adult), Nematodirus helvetianus (adult); Lungworm: Dictyocaulus viviparus (adult and L4); Cattle Grubs: Hypoderma bovis, Hypoderma lineatum Mites: Chorioptes bovis, Psoroptes ovis (Psoroptes communis var. bovis); Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Damalinia bovis; Horn flies: Haematobia irritans. To control infections and to protect from reinfection from Ostertagia ostertagi for 28 days after treatment and from Dictyocaulus viviparus for 42 days after treatment.
In sheep, oral moxidectin is indicated for the control of Haemonchus contortus (adult and L4), Teladosrsagia circumcincta & trifurcata (adult and L4), Trichostrongylus colubriformis, axei, & vitrinius (adult & L4), Cooperia curticei & oncophora (adult and L4), Oesophagostomum columbianum & venolosum (adult & L4), and Nematodirus battus, filicollis, & spathiger (adult & L4).
In horses and ponies, moxidectin is indicated for the treatment and control of the following stages of gastrointestinal parasites: Large strongyles: Strongylus vulgaris (adults and L4L5 arterial stages); Strongylus edentatus (adults and tissue stages); Triodontophorus brevicauda (adults); Triodontophorus serratus (adults); Small strongyles (adults and larvae): Cyathostomum spp. (adults); Cylicocyclus spp. (adults); Cylicostephanus spp. (adults); Gyalocephalus capitatus (adults); undifferentiated lumenal larvae; Encysted cyathostomes: late L3 and L4 mucosal cyathostome larvae; Ascarids: Parascaris equorum (adults and L4 larval stages); Pin worms: Oxyuris equi (adults and L4 larval stages); Hair worms: Trichostrongylus axei (adults); Large-mouth stomach worms: Habronema muscae (adults); Horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars). When combined with praziquantel, additional coverage against Anoplocephala spp. occurs.

Moxidectin Preparation Products And Raw materials

Raw materials

Preparation Products

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Moxidectin Suppliers

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View Lastest Price from Moxidectin manufacturers

Hebei Longbang Technology Co., Ltd
Product
Moxidectin 113507-06-5
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-22
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Moxidectin 113507-06-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
10000ton
Release date
2024-04-29
Hebei Saisier Technology Co., LTD
Product
Moxidectin 113507-06-5
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-26

113507-06-5, MoxidectinRelated Search:

Abamectin Moxifloxacin Ivermectin Nystatin MILBEMECTIN A3 CARVEOL TETRAHYDRO-PYRAN-4-ONE OXIME LAVANDULOL MILBEMECTIN A4 (+)-Dipentene ETHYL 2-METHYL-3-PENTENOATE (+/-)-LAVANDULOL 2-PROPYL-3-PENTENOIC ACID FEMA 3693 trans-3-Hydroxyhex-4-enoic acid, min. 95 % (1H-NMR) Moxidectin for system suitability Moxidectin HEPTA-4,6-DIENOIC ACID

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  • <font color="#ff0000">113507-06-5</font>
  • Moxicitin
  • Moxibustin
  • (2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-Dihydroxy-4-(methoxyimino)-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
  • (1R,4S,4'E,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
  • 113507-06-5
  • 507-06-5
  • C37H53NO8
  • API
  • MLSAnalytical Standards
  • Antibiotics
  • BacteriostaticAntibiotics
  • beta-Lactam StructureAlphabetic
  • Chemical Structure
  • Chromatography
  • M
  • Pharmacology Standards
  • Principle
  • CYDECTIN
  • METI - MZAntibiotics
  • Anthelmintic, antiparasitic.
  • 113507-06-5