chlormethine N-oxide hydrochloride Property

Melting point:

109-110°

EPA Substance Registry System

Nitrogen mustard (HN-2), N-oxide hydrochloride (302-70-5)

Safety

RIDADR 

3249

HazardClass 

6.1(a)

PackingGroup 

II

Hazardous Substances Data

302-70-5(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 60mg/kg

Hazard and Precautionary Statements (GHS)

chlormethine N-oxide hydrochloride Chemical Properties,Usage,Production

Definition

ChEBI: Nitrogen mustard N-oxide hydrochloride is a nitrogen mustard.

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cland NOx.

Carcinogenicity

Nitrogen mustard N-oxide is reportedly carcinogenic in mice and rats. Following subcutaneous administration in mice, it produced lung tumors, thymic lymphomas, and Harderian gland adenomas. Mice given two weekly injections either intravenously, intraperitoneally, or subcutaneously for 15 weeks showed an increase in lymphomas, fibrosarcomas, pulmonary adenomas, and liver hemangiomas. In rats given the material intravenously, it mainly produced lymphoreticular tumors and sarcomas. The preceding data were evaluated by the IARC and considered “sufficient evidence of carcinogenicity in animals.” Based on this evaluation and its mutagenic potential, the IARC classified nitrogen mustard N-oxide in Group 2B (possibly carcinogenic to humans).