chlormethine N-oxide hydrochloride
- Product Name
- chlormethine N-oxide hydrochloride
- CAS No.
- 302-70-5
- Chemical Name
- chlormethine N-oxide hydrochloride
- Synonyms
- Mbao hydrochloride;Hn20 hydrochloride;Mechlorethaminoxyde;Hn2 oxide hydrochloride;Chlormethine N-oxide HCl;mustine N-oxide hydrochloride;chlormethine N-oxide hydrochloride;NITROGENMUSTARDN-OXIDEHYDROCHLORIDE;MECHLORETHAMINE OXIDE HYDROCHLORIDE;2,2'-Dichloro-N-methyldiethylamine N-oxide hydrochloride
- CBNumber
- CB4875228
- Molecular Formula
- C5H12Cl3NO
- Formula Weight
- 208.51388
- MOL File
- 302-70-5.mol
chlormethine N-oxide hydrochloride Property
- Melting point:
- 109-110°
- EPA Substance Registry System
- Nitrogen mustard (HN-2), N-oxide hydrochloride (302-70-5)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Hazardous Substances Data
- 302-70-5(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 60mg/kg
N-Bromosuccinimide Price
- Product number
- CHM1026810
- Product name
- CHLORMETHINE N-OXIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.58
- Updated
- 2021/12/16
chlormethine N-oxide hydrochloride Chemical Properties,Usage,Production
Definition
ChEBI: Nitrogen mustard N-oxide hydrochloride is a nitrogen mustard.
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cland NOx.
Carcinogenicity
Nitrogen mustard N-oxide is reportedly carcinogenic in mice and rats. Following subcutaneous administration in mice, it produced lung tumors, thymic lymphomas, and Harderian gland adenomas. Mice given two weekly injections either intravenously, intraperitoneally, or subcutaneously for 15 weeks showed an increase in lymphomas, fibrosarcomas, pulmonary adenomas, and liver hemangiomas. In rats given the material intravenously, it mainly produced lymphoreticular tumors and sarcomas. The preceding data were evaluated by the IARC and considered “sufficient evidence of carcinogenicity in animals.” Based on this evaluation and its mutagenic potential, the IARC classified nitrogen mustard N-oxide in Group 2B (possibly carcinogenic to humans).