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Trimethylamine N-oxide

Product Name
Trimethylamine N-oxide
CAS No.
1184-78-7
Chemical Name
Trimethylamine N-oxide
Synonyms
TMAO;Trimethylamine oxide;N,N-dimethylmethanamine oxide;trimethyloxamine;Trimetlylamine Oxide;Triox;TMANO Anhydrous;TRIMETHYLAMINOXIDE;rimethylamineN-oxide;TRIMETHYLAMINE N-OXIDE
CBNumber
CB6140124
Molecular Formula
C3H9NO
Formula Weight
75.11
MOL File
1184-78-7.mol
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Trimethylamine N-oxide Property

Melting point:
220-222 °C (lit.)
Boiling point:
133.8°C (rough estimate)
Density 
0.9301 (rough estimate)
vapor pressure 
23.5Pa at 20℃
refractive index 
1.4698 (estimate)
FEMA 
4245 | TRIMETHYLAMINE OXIDE
storage temp. 
Hygroscopic, Room Temperature, under inert atmosphere
solubility 
Chloroform, DMSO, Methanol (Slightly)
pka
4.65(at 25℃)
form 
Solid
color 
Pale Yellow
Odor
odorless
Water Solubility 
793g/L at 24.5℃
Merck 
14,9711
JECFA Number
1614
Stability:
Hygroscopic
LogP
-2.79
EPA Substance Registry System
Methanamine, N,N-dimethyl-, N-oxide (1184-78-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
2904.20.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
317594
Product name
Trimethylamine N-oxide
Purity
95%
Packaging
1g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
317594
Product name
Trimethylamine N-oxide
Purity
95%
Packaging
5g
Price
$163
Updated
2024/03/01
TCI Chemical
Product number
T1362
Product name
Trimethylamine N-Oxide Anhydrous
Purity
>95.0%(T)
Packaging
1g
Price
$43
Updated
2024/03/01
TCI Chemical
Product number
T1362
Product name
Trimethylamine N-Oxide Anhydrous
Purity
>95.0%(T)
Packaging
5g
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
17354
Product name
Trimethylamine N-oxide
Purity
≥95%
Packaging
500mg
Price
$32
Updated
2024/03/01
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Trimethylamine N-oxide Chemical Properties,Usage,Production

Description

Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.

Chemical Properties

White crystalline powder

Chemical Properties

Colorless to yellow solid; odorless.

Uses

Trimethylamine?N-oxide can be used:

  • As a demetallation?and decarbonylation?reagent for organometallic compounds.
  • To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
  • To mediate the conversion of thiols to disulfides.

Definition

ChEBI: An N-oxide derived from triethylamine.

General Description

Trimethylamine?N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.

Flammability and Explosibility

Not classified

Trimethylamine N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethylamine N-oxide Suppliers

Yantai Sheng Kai Lun Biological Products Co. , Ltd.
Tel
3119594100
Email
mark@sklnchem.cn
Country
China
ProdList
7363
Advantage
58
Sichuan BioCrick Biotech Co., Ltd
Tel
28-85433893
Email
info@biocrick.com
Country
CHINA
ProdList
4988
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
SelectLab Chemicals GmbH
Tel
+49-(0)2383-919350
Fax
+49-(0)2383-919354
Email
info@selectlab.de
Country
Germany
ProdList
394
Advantage
55
Dr. J. Pharmachem (India)
Tel
+91 20 24332987
Fax
+91 20 24332137
Email
info@jpharmachem.com
Country
India
ProdList
97
Advantage
55
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
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View Lastest Price from Trimethylamine N-oxide manufacturers

Hebei Yibangte Import and Export Co. , Ltd.
Product
Trimethylamine N-oxide 1184-78-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
Trimethylamine N-oxide 1184-78-7
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000KG
Release date
2019-12-31
Shaanxi Dideu Medichem Co. Ltd
Product
trimethylamine N-oxide 1184-78-7
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000KG
Release date
2020-01-07

1184-78-7, Trimethylamine N-oxideRelated Search:


  • n,n-dimethyl-methanaminn-oxide
  • TMAO
  • Trimethylamine oxide
  • trimethyloxamine
  • Triox
  • TRIMETHYLAMINE N-OXIDE
  • TRIMETHYLAMINE OXIDE HYDROCHLORIDE
  • TRIMETHYLAMINE N-OXIDE HYDROCHLORIDE
  • trimethyl-oxido-ammonium
  • TRIMETHYLAMINOXIDE
  • Trimethylamine N-Oxide Anhydrous
  • Trimethylamine N-oxide,98%
  • Trimethylamine N-oxide,TMANO
  • TriMethylaMine N-oxide 98%
  • Trimethylamine <i>N</i>-Oxide Anhydrous
  • Trimetlylamine Oxide
  • N,N-Dimethylmethanamine N-oxide
  • Methanamine,N,N-dimethyl-,N-oxide
  • N,N-dimethylmethanamine oxide
  • TMANO Anhydrous
  • rimethylamineN-oxide
  • Trimethylamine N-oxide ISO 9001:2015 REACH
  • Trimethylamine Oxide (TMAO)
  • trimethylamine N-oxide(1184-78-7)
  • 1184-78-7
  • Others
  • Synthetic Reagents
  • Oxidation
  • Oxidation
  • Synthetic Organic Chemistry