ChemicalBook > CAS DataBase List > Trimethylamine N-oxide

Trimethylamine N-oxide

Product Name
Trimethylamine N-oxide
CAS No.
1184-78-7
Chemical Name
Trimethylamine N-oxide
Synonyms
TMAO;Trimethylamine oxide;N,N-dimethylmethanamine oxide;trimethyloxamine;Trimetlylamine Oxide;Triox;TMANO Anhydrous;TRIMETHYLAMINOXIDE;rimethylamineN-oxide;TRIMETHYLAMINE N-OXIDE
CBNumber
CB6140124
Molecular Formula
C3H9NO
Formula Weight
75.11
MOL File
1184-78-7.mol
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Trimethylamine N-oxide Property

Melting point:
220-222 °C (lit.)
Boiling point:
133.8°C (rough estimate)
Density 
0.9301 (rough estimate)
vapor pressure 
23.5Pa at 20℃
refractive index 
1.4698 (estimate)
FEMA 
4245 | TRIMETHYLAMINE OXIDE
storage temp. 
Hygroscopic, Room Temperature, under inert atmosphere
solubility 
Chloroform, DMSO, Methanol (Slightly)
pka
4.65(at 25℃)
form 
Solid
color 
Pale Yellow
Odor
odorless
Water Solubility 
793g/L at 24.5℃
Merck 
14,9711
JECFA Number
1614
Stability:
Hygroscopic
LogP
-2.79
EPA Substance Registry System
Methanamine, N,N-dimethyl-, N-oxide (1184-78-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
2904.20.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
317594
Product name
Trimethylamine N-oxide
Purity
95%
Packaging
1g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
317594
Product name
Trimethylamine N-oxide
Purity
95%
Packaging
5g
Price
$163
Updated
2024/03/01
TCI Chemical
Product number
T1362
Product name
Trimethylamine N-Oxide Anhydrous
Purity
>95.0%(T)
Packaging
1g
Price
$43
Updated
2024/03/01
TCI Chemical
Product number
T1362
Product name
Trimethylamine N-Oxide Anhydrous
Purity
>95.0%(T)
Packaging
5g
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
17354
Product name
Trimethylamine N-oxide
Purity
≥95%
Packaging
500mg
Price
$32
Updated
2024/03/01
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Trimethylamine N-oxide Chemical Properties,Usage,Production

Description

Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.

Chemical Properties

White crystalline powder

Chemical Properties

Colorless to yellow solid; odorless.

Uses

Trimethylamine?N-oxide can be used:

  • As a demetallation?and decarbonylation?reagent for organometallic compounds.
  • To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
  • To mediate the conversion of thiols to disulfides.

Definition

ChEBI: An N-oxide derived from triethylamine.

General Description

Trimethylamine?N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.

Flammability and Explosibility

Not classified

Trimethylamine N-oxide Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Toluene Trimethylamine

Preparation Products

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View Lastest Price from Trimethylamine N-oxide manufacturers

Hebei Fengjia New Material Co., Ltd
Product
Trimethylamine N-oxide 1184-78-7
Price
US $120.00/g
Min. Order
1g
Purity
0.99
Supply Ability
1000000
Release date
2024-08-16
Hebei Kingfiner Technology Development Co.Ltd
Product
Trimethylamine N-oxide 1184-78-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-12-26
Career Henan Chemical Co
Product
TRIMETHYLAMINE N-OXIDE HYDROCHLORIDE 1184-78-7
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

1184-78-7, Trimethylamine N-oxideRelated Search:

TRIMETHYLAMINE OXIDE DIHYDRATE Ammothamnine CLOZAPINE N-OXIDE Trimethylamine N-oxide N,N-DIMETHYLOCTYLAMINE-N-OXIDE 4-Methylmorpholine N-oxide LDAO DDAO 4-Methylmorpholine N-oxide monohydrate SCOPOLAMINE N-OXIDE HYDROBROMIDE DIMETHYLSTEARYLAMINE OXIDE MYRISTYL DIMETHYLAMINE OXIDE Trimethylamine isatidine ATROPINE N-OXIDE HYDROCHLORIDE 2,2'-(BENZYLIMINO)-DIETHANOL N-OXIDE TRIETHYLAMINE N-OXIDE CODEINE N-OXIDE

  • n,n-dimethyl-methanaminn-oxide
  • TMAO
  • Trimethylamine oxide
  • trimethyloxamine
  • Triox
  • TRIMETHYLAMINE N-OXIDE
  • TRIMETHYLAMINE OXIDE HYDROCHLORIDE
  • TRIMETHYLAMINE N-OXIDE HYDROCHLORIDE
  • trimethyl-oxido-ammonium
  • TRIMETHYLAMINOXIDE
  • Trimethylamine N-Oxide Anhydrous
  • Trimethylamine N-oxide,98%
  • Trimethylamine N-oxide,TMANO
  • TriMethylaMine N-oxide 98%
  • Trimethylamine <i>N</i>-Oxide Anhydrous
  • Trimetlylamine Oxide
  • N,N-Dimethylmethanamine N-oxide
  • Methanamine,N,N-dimethyl-,N-oxide
  • N,N-dimethylmethanamine oxide
  • TMANO Anhydrous
  • rimethylamineN-oxide
  • Trimethylamine N-oxide ISO 9001：2015 REACH
  • Trimethylamine Oxide (TMAO)
  • trimethylamine N-oxide(1184-78-7)
  • anhydrous Trimethylamine N-oxide
  • Trimethylamine N-Oxide in Methanol:Water=1:1
  • 1184-78-7
  • Others
  • Synthetic Reagents
  • Oxidation
  • Oxidation
  • Synthetic Organic Chemistry