ChemicalBook > CAS DataBase List > tolonidine

tolonidine

Product Name
tolonidine
CAS No.
4201-22-3
Chemical Name
tolonidine
Synonyms
ST-375;tolonidine;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
CBNumber
CB4875314
Molecular Formula
C10H12ClN3
Formula Weight
209.68
MOL File
4201-22-3.mol
More
Less

tolonidine Property

Melting point:
148-150°
Boiling point:
314.0±52.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.41(at 25℃)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
SYN5523
Product name
Tolonidine
Packaging
10mg
Price
$104
Updated
2021/12/16
AK Scientific
Product number
SYN5523
Product name
Tolonidine
Packaging
50mg
Price
$336
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012694
Product name
TOLONIDINE
Purity
95.00%
Packaging
5MG
Price
$495.19
Updated
2021/12/16
More
Less

tolonidine Chemical Properties,Usage,Production

Originator

Euctan,Essex,Switz.,1978

Definition

ChEBI: Tolonidine is a substituted aniline.

Manufacturing Process

43 g of the thiourea compound (melting point 124°C) obtained in known fashion from 2-chloro-4-methylaniline and ammonium thiocyanate and 20 cc of methyl iodide were dissolved in 200 cc of methanol, and the solution was refluxed for two hours.1 Thereafter, the solvent was evaporated in vacuo, leaving 73.2 g of the isothiouronium hydroiodide of the formula as a residue. This isothiouronium salt was admixed with 20 cc of ethylenediamine, and the mixture was heated for about 30 minutes at 150°C to 160°C, accompanied by stirring; methyl mercaptan escaped during that time. Subsequently, the reaction mixture was taken up in hot dilute acetic acid, and the resulting solution was made alkaline with 2 N sodium hydroxide. A precipitate formed, which was separated by vacuum filtration, washed with water and dried. It was identified to be 2-(2'-chloro-4'-methylphenyl)-amino-1,3- diazacyclopentene-(2) having a melting point of 142°C to 145°C. The yield was 10.2 g.
The nitrate of the base, obtained by acidifying a solution of the free base with nitric acid, had a melting point of 162°C to 164°C and was soluble in water and methanol.

Therapeutic Function

Antihypertensive

tolonidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tolonidine Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58

4201-22-3, tolonidineRelated Search:


  • tolonidine
  • N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
  • ST-375
  • 1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
  • 4201-22-3
  • C10H12ClN3