Vepdegestrant (ARV-471)

Product Name: Vepdegestrant (ARV-471)
CAS No.: 2229711-68-4
Chemical Name: Vepdegestrant (ARV-471)
Synonyms: ARV-471;ARV471 ，S9862;Vepdegestrant;Vepdegestrant（ARV-471）;ARV-471, 10 mM in DMSO;3-(4-hydroxy-6-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-(4-((1-(4-((1R,2S)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;oral,Inhibitor,breast cancer,PROTAC,E3 ligase,inhibit,hetero-bifunctional,ubiquitylation,ARV-471,PROTACs,Estrogen Receptor/ERR,ARV 471,estrogen receptor,ARV471,proteasome;(3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione;2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-
CBNumber: CB48816045
Molecular Formula: C45H49N5O4
Formula Weight: 723.9
MOL File: 2229711-68-4.mol

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Vepdegestrant (ARV-471) Property

Density: 1.275±0.06 g/cm3(Predicted)
solubility: DMSO : 110 mg/mL (151.95 mM; Need ultrasonic)
pka: 10.36±0.60(Predicted)
form: Solid
color: White to off-white
InChIKey: TZZDVPMABRWKIZ-XMOGEVODSA-N
SMILES: N1C(=O)CC[C@H](N2CC3=C(C2=O)C=CC(N2CCN(CC4CCN(C5=CC=C([C@@H]6C7=C(C=C(O)C=C7)CC[C@@H]6C6=CC=CC=C6)C=C5)CC4)CC2)=C3)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 43002
Product name: ARV-471
Purity: ≥98%
Packaging: 1mg
Price: $329
Updated: 2026/04/30

Cayman Chemical

Product number: 43002
Product name: ARV-471
Purity: ≥98%
Packaging: 5mg
Price: $823
Updated: 2026/04/30

Cayman Chemical

Product number: 43002
Product name: ARV-471
Purity: ≥98%
Packaging: 10mg
Price: $1316
Updated: 2026/04/30

ACHEMBLOCK

Product number: Y230345
Product name: ARV-471
Purity: 98%
Packaging: 5MG
Price: $755
Updated: 2026/05/27

ACHEMBLOCK

Product number: Y230345
Product name: ARV-471
Purity: 98%
Packaging: 25MG
Price: $1595
Updated: 2026/05/27

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Vepdegestrant (ARV-471) Chemical Properties,Usage,Production

Uses

ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. It is developed for the research of breast cancer.

Biological Activity

ARV-471 is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. It leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. ARV-471 robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM.

in vivo

Vepdegestrant (3-30 mpk, p.o, daily) inhibits tumor growth in estradiol-dependent MCF7 xenografts and reduces tumor ER protein^[2].

Vepdegestrant (ARV-471) Preparation Products And Raw materials

Raw materials

Preparation Products

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Vepdegestrant (ARV-471) Suppliers

China 69 United States 3 Global 72

Tianjin Lanshu Pharmaceutical Technology Co., Ltd

Tel: 15210678165
Email: hanyachao@163.com
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Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
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Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengpharma@126.co 18616377689
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Country: China
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Changzhou Borl Biotechnology Co.,LTD

Tel: 13606124132;13656121842
Email: luyan0021@163.com
Country: China
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Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
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ChemFuture PharmaTech (Jiangsu) Ltd

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
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Nanjing Chemlin Chemical Co., Ltd

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Email: info@chemlin.com.cn
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
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Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939; 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15781
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2229711-68-4, Vepdegestrant (ARV-471)Related Search:

2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-

ARV-471

Vepdegestrant

Vepdegestrant（ARV-471）

(S)-3-(5-(4-((1-(4-((1R,2S)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

oral,Inhibitor,breast cancer,PROTAC,E3 ligase,inhibit,hetero-bifunctional,ubiquitylation,ARV-471,PROTACs,Estrogen Receptor/ERR,ARV 471,estrogen receptor,ARV471,proteasome

3-(4-hydroxy-6-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione

ARV-471, 10 mM in DMSO

ARV471 ，S9862

(3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione

2229711-68-4

C45H49N5O4

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