6,7-dimethoxyphthalide Property

Melting point:

103℃

Boiling point:

290.62°C (rough estimate)

Density 

1.2534 (rough estimate)

refractive index 

1.5430 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml

form 

A crystalline solid

color 

White to off-white

Water Solubility 

2.5g/L(25 ºC)

Safety

HS Code 

2932990090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

6,7-dimethoxyphthalide Chemical Properties,Usage,Production

Synthesis

Compound 7 (91.0 g, 0.5 mol), HCHO solution (81 g, 1.0 mol), HCl (80 g, 0.8 mol) and AcOH (200 g) were heated at 50~60 °C for 24 h to obtain a clear solution, which was then poured into cold water Chemicalbook (1kg). The resulting solid was collected by suction filtration, washed with water (60 g x 3), and dried at 50 °C to give crude cinnamon 8 (95 g) as a tan solid, which was purified by recrystallization from 90% MeOH/H2O (180 g) ) to obtain purified Meconin.

Chemical Properties

White Solid

Uses

A lactone of meconinic acid, extracted from opium. Meconin is a marker for illicit opiate use.

Definition

ChEBI: Meconine is a member of 2-benzofurans.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 3369, 1987 DOI: 10.1016/S0040-4039(00)95515-1