6,7-dimethoxyphthalide
Synthesis- Product Name
- 6,7-dimethoxyphthalide
- CAS No.
- 569-31-3
- Chemical Name
- 6,7-dimethoxyphthalide
- Synonyms
- Opianyl;Meconine;NSC 35547;Meconic lactone;6,7-dimethoxyphthalide;Noscapine Impurity 4(Meconine);Meconin (1.0 mg/mL in Chloroform);6,7-dimethoxy-3H-2-benzofuran-1-one;6,7-DiMethoxy-3H-1-isobenzofuranone;6,7-dimethoxy-3H-isobenzofuran-1-one
- CBNumber
- CB4883065
- Molecular Formula
- C10H10O4
- Formula Weight
- 194.184
- MOL File
- 569-31-3.mol
6,7-dimethoxyphthalide Property
- Melting point:
- 103℃
- Boiling point:
- 290.62°C (rough estimate)
- Density
- 1.2534 (rough estimate)
- refractive index
- 1.5430 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- color
- White to off-white
- Water Solubility
- 2.5g/L(25 ºC)
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9001140
- Product name
- Meconin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 9001140
- Product name
- Meconin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 9001140
- Product name
- Meconin
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $468
- Updated
- 2024/03/01
- Product number
- OR928256
- Product name
- 6,7-Dimethoxyisobenzofuran-1(3H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 6419AJ
- Product name
- 6,7-Dimethoxyisobenzofuran-1(3H)-one
- Packaging
- 1g
- Price
- $284
- Updated
- 2021/12/16
6,7-dimethoxyphthalide Chemical Properties,Usage,Production
Synthesis
Compound 7 (91.0 g, 0.5 mol), HCHO solution (81 g, 1.0 mol), HCl (80 g, 0.8 mol) and AcOH (200 g) were heated at 50~60 °C for 24 h to obtain a clear solution, which was then poured into cold water Chemicalbook (1kg). The resulting solid was collected by suction filtration, washed with water (60 g x 3), and dried at 50 °C to give crude cinnamon 8 (95 g) as a tan solid, which was purified by recrystallization from 90% MeOH/H2O (180 g) ) to obtain purified Meconin.
Chemical Properties
White Solid
Uses
A lactone of meconinic acid, extracted from opium. Meconin is a marker for illicit opiate use.
Definition
ChEBI: Meconine is a member of 2-benzofurans.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 3369, 1987 DOI: 10.1016/S0040-4039(00)95515-1
6,7-dimethoxyphthalide Preparation Products And Raw materials
Raw materials
Preparation Products
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