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fenozolone

Product Name
fenozolone
CAS No.
15302-16-6
Chemical Name
fenozolone
Synonyms
LD-3394;Ordinator;fenozolone;Phenozolone;2-Ethylamino-5-phenyl-2-oxazolin-4-one;2-(Ethylamino)-5-phenyl-2-oxazolin-4-one;4(5H)-Oxazolone, 2-(ethylamino)-5-phenyl-
CBNumber
CB4904971
Molecular Formula
C11H12N2O2
Formula Weight
204.23
MOL File
15302-16-6.mol
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fenozolone Property

Melting point:
148°
Boiling point:
306.8±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
1.83±0.40(Predicted)
color 
White to Off-White
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Safety

Toxicity
LD50 in white mice (g/kg): 0.425 orally; 0.175 i.p. (BE 613985)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
94767
Product name
Fenozolone
Packaging
25mg
Price
$465
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0011439
Product name
FENOZOLONE
Purity
95.00%
Packaging
5MG
Price
$497.76
Updated
2021/12/16
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fenozolone Chemical Properties,Usage,Production

Originator

Fenozolone,Shanghai Lansheng

Uses

Fenozolone is a psychoactive drug and stimulant related to pemoline and 4-methylaminorex which acts as a norepinephrine-dopamine releasing agent (NDRA).

Definition

ChEBI: Fenozolone is a member of benzenes.

Manufacturing Process

Into a 3-necked spherical flask of 1 L provided with a dropping funnel, a condenser surmounted by a calcium chloride tube and a mechanical stirrer, is introduced a suspension of 17.6 g (0.2 mol) of ethyl urea in 150 ml of anhydrous benzene. There is added through the dropping funnel in 20 minutes a solution of 18.9 g (0.1 mol) α-chlorophenyl-acetyl chloride in 300 ml of benzene. The mixture is left at ambient temperature for 15 minutes and is then heated under reflux on the water bath with stirring for 5 hours. The benzene solution is decanted at elevated temperature in order to separate it from an oil deposited on the bottom of the flask, the benzene is driven off on the water bath, the last traces removed in vacuum, the crystalline residue is triturated in a mortar in about 200 ml of water, and the crystalline solid is separated off and is with water and dried in vacuum over phosphorus pentoxide. There are thus recovered 19.6 g (yield 82%) of 1-(2-chloro-2- phenyl-acetyl)-3-ethyl-urea, which when recrystallized from 80 ml of benzene, takes the form of white crystals soluble in benzene but insoluble in water. The product has melting point 146°C. To a suspension of 39 g (0.163 mol) of 1-(2-chloro-2-phenyl-acetyl)-3-ethylurea in 250 ml of anhydrous ethyl alcohol is added a sodium ethoxide solution containing 3.75 g (0.163 mol) of sodium dissolved in 250 ml of ethyl alcohol. The mixture is heated under reflux for 2 hours and left overnight at ambient temperature. The precipitated sodium chloride is separated off and copiously washed with alcohol. The alcohol is driven off from the filtrate on the water bath, the oily residue is triturated in 20 ml of iced water, and the solid formed is refrigerated for several hours, separated, washed with water and dried in vacuum over phosphorus pentoxide. The 5-phenyl-2-ethylamino-4-oxazolinone (fenozolone) obtained is recrystallized from anhydrous benzene. It then forms a white crystalline compound soluble in benzene and insoluble in water, MP: 148°C.

Therapeutic Function

Psychostimulant

fenozolone Preparation Products And Raw materials

Raw materials

Preparation Products

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fenozolone Suppliers

BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31121
Advantage
58
Shaanxi kelkai Pharmaceutical Technology Co., Ltd
Tel
029-029-2148545164 17392779578
Email
2148545164@qq.com
Country
China
ProdList
4818
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Guangzhou CATO Research Chemicals Inc.
Tel
+86-020-81960175-617 +8615602392859
Email
Intermediate@cato-chem.com
Country
China
ProdList
8047
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
LEAP CHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
24727
Advantage
58

15302-16-6, fenozoloneRelated Search:


  • fenozolone
  • 2-(Ethylamino)-5-phenyl-2-oxazolin-4-one
  • 2-Ethylamino-5-phenyl-2-oxazolin-4-one
  • LD-3394
  • Ordinator
  • Phenozolone
  • 4(5H)-Oxazolone, 2-(ethylamino)-5-phenyl-
  • 15302-16-6