fenozolone
- Product Name
- fenozolone
- CAS No.
- 15302-16-6
- Chemical Name
- fenozolone
- Synonyms
- LD-3394;Ordinator;fenozolone;Phenozolone;2-Ethylamino-5-phenyl-2-oxazolin-4-one;2-(Ethylamino)-5-phenyl-2-oxazolin-4-one;4(5H)-Oxazolone, 2-(ethylamino)-5-phenyl-
- CBNumber
- CB4904971
- Molecular Formula
- C11H12N2O2
- Formula Weight
- 204.23
- MOL File
- 15302-16-6.mol
fenozolone Property
- Melting point:
- 148°
- Boiling point:
- 306.8±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.83±0.40(Predicted)
- color
- White to Off-White
Safety
- Toxicity
- LD50 in white mice (g/kg): 0.425 orally; 0.175 i.p. (BE 613985)
N-Bromosuccinimide Price
- Product number
- 94767
- Product name
- Fenozolone
- Packaging
- 25mg
- Price
- $465
- Updated
- 2021/12/16
- Product number
- API0011439
- Product name
- FENOZOLONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.76
- Updated
- 2021/12/16
fenozolone Chemical Properties,Usage,Production
Originator
Fenozolone,Shanghai Lansheng
Uses
Fenozolone is a psychoactive drug and stimulant related to pemoline and 4-methylaminorex which acts as a norepinephrine-dopamine releasing agent (NDRA).
Definition
ChEBI: Fenozolone is a member of benzenes.
Manufacturing Process
Into a 3-necked spherical flask of 1 L provided with a dropping funnel, a condenser surmounted by a calcium chloride tube and a mechanical stirrer, is introduced a suspension of 17.6 g (0.2 mol) of ethyl urea in 150 ml of anhydrous benzene. There is added through the dropping funnel in 20 minutes a solution of 18.9 g (0.1 mol) α-chlorophenyl-acetyl chloride in 300 ml of benzene. The mixture is left at ambient temperature for 15 minutes and is then heated under reflux on the water bath with stirring for 5 hours. The benzene solution is decanted at elevated temperature in order to separate it from an oil deposited on the bottom of the flask, the benzene is driven off on the water bath, the last traces removed in vacuum, the crystalline residue is triturated in a mortar in about 200 ml of water, and the crystalline solid is separated off and is with water and dried in vacuum over phosphorus pentoxide. There are thus recovered 19.6 g (yield 82%) of 1-(2-chloro-2- phenyl-acetyl)-3-ethyl-urea, which when recrystallized from 80 ml of benzene, takes the form of white crystals soluble in benzene but insoluble in water. The product has melting point 146°C. To a suspension of 39 g (0.163 mol) of 1-(2-chloro-2-phenyl-acetyl)-3-ethylurea in 250 ml of anhydrous ethyl alcohol is added a sodium ethoxide solution containing 3.75 g (0.163 mol) of sodium dissolved in 250 ml of ethyl alcohol. The mixture is heated under reflux for 2 hours and left overnight at ambient temperature. The precipitated sodium chloride is separated off and copiously washed with alcohol. The alcohol is driven off from the filtrate on the water bath, the oily residue is triturated in 20 ml of iced water, and the solid formed is refrigerated for several hours, separated, washed with water and dried in vacuum over phosphorus pentoxide. The 5-phenyl-2-ethylamino-4-oxazolinone (fenozolone) obtained is recrystallized from anhydrous benzene. It then forms a white crystalline compound soluble in benzene and insoluble in water, MP: 148°C.
Therapeutic Function
Psychostimulant
fenozolone Preparation Products And Raw materials
Raw materials
Preparation Products
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