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nalbuphine

Product Name
nalbuphine
CAS No.
20594-83-6
Chemical Name
nalbuphine
Synonyms
C07251;NALBUPNINE;Nalbuphinebase;2H3]-Nalbuphine;NaltrexoneImpurity24;NETZHAKZCGBWSS-CEDHKZHLSA-N;Nalbuphine (1.0mg/ml in Acetonitrile);Nalbuphine (base and/or unspecified salts);17-[Cyclobutylmethyl]-4,5α-epoxymorphinan-3,6α,14-triol;Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5α,6α)- (9CI)
CBNumber
CB4918699
Molecular Formula
C21H27NO4
Formula Weight
357.45
MOL File
20594-83-6.mol
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nalbuphine Property

Melting point:
230.5°
Boiling point:
566.6±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
solubility 
soluble in Methanol
form 
Solid
pka
9.39±0.60(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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nalbuphine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Originator

Nubain,Du Pont,US,1979

Uses

Mixed opioid agonist-antagonist. Analgesic (narcotic).

Uses

Nalbuphine is a mixed opioid agonist-antagonist. Nalbuphine is an analgesic (narcotic).

Definition

ChEBI: Nalbuphine is an organic heteropentacyclic compound. It has a role as a mu-opioid receptor antagonist and an opioid analgesic. It derives from a hydride of a morphinan.

Manufacturing Process

To a slurry of 110.5 g of 14-hydroxydihydronormorphinone in 2.5 liters of methylene chloride and 280 ml of triethylamine was added a solution of 106 g of cyclobutanecarboxylic acid chloride in 500 ml of methylene chloride. The temperature of the reaction mixture was maintained at 20°C to 25°C during the addition. After 5 minutes the reaction mixture was brought to reflux and heated for 5 hours.
It was then cooled, washed with water, dried over sodium sulfate and evaporated to dryness. The residue was crystallized from benzene and pentane to give 138.5 g of the dicyclobutanecarbonyl derivative, melting point about 112°C (dec.).
The dicyclobutanecarbonyl derivative (136.7 g) was dissolved in 200 ml of tetrahydrofuran and added dropwise to a suspension of 34.2 g of lithium aluminum hydride in 1 liters of tetrahydrofuran. The temperature of the mixture rose to reflux during the addition. Reflux was maintained for 2 hours after the addition was completed. After cooling, 110 ml of ethyl acetate was added dropwise, followed by 30 ml of water, followed by a solution of 53 g of ammonium chloride in 125 ml of water. The resulting mixture was filtered and the inorganic precipitate was washed with methanol. Evaporation of the combined filtrates gave 66 g of N-cyclobutylmethyl-14-hydroxydihydronormorphinone, melting point 229°C to 231°C.

brand name

Nubain (Endo).

Therapeutic Function

Analgesic

nalbuphine Preparation Products And Raw materials

Raw materials

Preparation Products

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nalbuphine Suppliers

20594-83-6, nalbuphine Related Search:


  • NETZHAKZCGBWSS-CEDHKZHLSA-N
  • Nalbuphinebase
  • 17-[Cyclobutylmethyl]-4,5α-epoxymorphinan-3,6α,14-triol
  • NALBUPNINE
  • Nalbuphine (base and/or unspecified salts)
  • C07251
  • Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5α,6α)- (9CI)
  • Nalbuphine (1.0mg/ml in Acetonitrile)
  • 2H3]-Nalbuphine
  • NaltrexoneImpurity24
  • 20594-83-6
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals