BUTORPHANOL
- Product Name
- BUTORPHANOL
- CAS No.
- 42408-82-2
- Chemical Name
- BUTORPHANOL
- Synonyms
- 17-(cyclobutylmethyl)-morphinan-14-diol;C06863;l-BC 2627;BUTORPHANOL;Levo-BC 2627;BC 2627, (-)-;(-)-Butorphanol;17-(cyclobutylmethyl)morphinan-3,14-diol;l-3,14-Dihydroxy-N-(cyclobutylmethyl)morphinan;(-)-17-(Cyclobutylmethyl)-3,14b-dihydroxymorphinan
- CBNumber
- CB6728719
- Molecular Formula
- C21H29NO2
- Formula Weight
- 327.46
- MOL File
- 42408-82-2.mol
BUTORPHANOL Property
- Melting point:
- 215-217°
- alpha
- D -70.0° (c = 0.1 in methanol)
- Boiling point:
- 507.3±50.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- pka
- pKa 8.6 (Uncertain)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
BUTORPHANOL Chemical Properties,Usage,Production
Originator
Stadol,Bristol-Myers,US,1978
Uses
Mixed opioid agonist-antagonist. Analgesic (narcotic); antitussive. Controlled substance.
Definition
ChEBI: Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is sed as its (S,S)-tartaric acid salt for relief or moderate to severe pain.
Manufacturing Process
A mixture of 1.0 g (2.58 mmols) of N-cyclobutylmethyl-14-hydroxy-9- methoxymorphinan and 10 ml of 48% HBr was refluxed, under a nitrogen atmosphere, during five minutes. After cooling, the reaction mixture was diluted with water and made basic with aqueous ammonium hydroxide. The aquous basic mixture was extracted with chloroform and the combined chloroform extracts were dried over anhyrous sodium sulfate. After evaporation of the solvent, the residual oil (730 mg) was taken up in dry ether and the resulting solution filtered through celite-charcoal. The filtrate was treated with a saturated solution of hydrogen chloride in dry ether. The hydrochloride salt thus obtained was collected by filtration and recrystallized from a methanol-acetone mixture to yield 565 mg (56.5%)of Butorphanol hydrochloride crystals melting at 272°-274°C (decomposition).
brand name
Stadol (Bristol-Myers Squibb).
Therapeutic Function
Analgesic, Antitussive
Biological Functions
Butorphanol (Stadol) is chemically related to levorphanol
but pharmacologically similar in action to pentazocine.
As an opioid antagonist it is nearly 30 times as
potent as pentazocine and has one-fortieth the potency
of naloxone. It is a potent opioid analgesic indicated for
the relief of moderate to severe pain. Its potency is 7
times that of morphine and 20 times that of pentazocine
as an analgesic. Its onset of action is similar to that of
morphine.The side effects and signs of toxicity are similar
to those produced by pentazocine. It produces excitatory
effects and sedation and precipitates withdrawal
in opioid-dependent patients. Although generally administered
parenterally because of its low bioavailability
following oral administration, it is also unique in that
a nasal spray formulation is available.The nasal spray is
indicated for the relief of postoperative pain and migraine
headache. The low molecular weight of butorphanol,
its high lipophilicity, and its lack of vasoconstrictor
effects make it particularly suitable for nasal
administration.
Nasal administration of butorphanol decreases the
onset of action to 15 minutes and decreases the firstpass
effect of the drug, which increases bioavailability.
Generally the patient sprays a set dose of 1 mg per hour
for 2 hours. The duration of action is 4 to 5 hours.
The convenience of such administration is a major advantage to patients requiring repeat dosing. The
abuse potential following such administration has not
been extensively studied, although it is thought to be
small. Butorphanol is not a federally controlled
(“scheduled”) drug, so physicians are not required to
obtain the licenses and security safeguards required for
other opioid analgesics.
Adverse effects, contraindications, and drug interactions
are similar to those for pentazocine and morphine.
General Description
Structurally, butorphanol is a morphinan and shares the samecyclobutyl methyl group on the nitrogen as nalbuphine. Likenalbuphine, butorphanol is an agonist at the κ-receptor but atthe μ-receptor butorphanol is both a partial agonist and anantagonist. The affinity for opioid receptors in vitro is1:4:25 for the μ-, δ-, and κ-receptors respectively. Thehigh affinity for the κ-receptors is proposed to give butorphanolits analgesic properties and is also responsible for theCNS adverse effects such as hallucinations, psychosis, andparanoid reactions. Butorphanol binds with μ-receptors as apartial agonist, and administration to humans maintained onhigh-potency μ-agonists such as morphine may precipitatewithdrawal. Butorphanol was found to produce convulsionsin morphine-deprived, morphine-dependent monkeys.