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Butorphanol tartrate

Product Name
Butorphanol tartrate
CAS No.
58786-99-5
Chemical Name
Butorphanol tartrate
Synonyms
torate;stadol;D00837;Moradol;torbutrol;NIH 10275;Torbugesic;Stadol (tn);oate(1:1)(salt);BUTORPHANOL TARTRATE
CBNumber
CB0181202
Molecular Formula
C25H35NO8
Formula Weight
477.55
MOL File
58786-99-5.mol
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Butorphanol tartrate Property

Melting point:
217-219°
alpha 
D22 -64.0° (c = 0.4 in methanol)
storage temp. 
2-8°C
CAS DataBase Reference
58786-99-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-63
Safety Statements 
22-26-36/37/39
RIDADR 
1544
WGK Germany 
3
RTECS 
QC7795000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2933492250
Toxicity
LD50 in mice, rats (mg/kg): 40-57, 17-20 i.v.; 395-527, 570-756 orally (Heel)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B9156
Product name
Butorphanol (+)-tartrate salt
Purity
≥99%
Packaging
100mg
Price
$257
Updated
2023/01/07
Sigma-Aldrich
Product number
1082504
Product name
Butorphanol tartrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350mg
Price
$551
Updated
2021/12/16
Cayman Chemical
Product number
23812
Product name
Butorphanol (tartrate)
Packaging
1mg
Price
$39
Updated
2023/01/06
Cayman Chemical
Product number
23812
Product name
Butorphanol (tartrate)
Packaging
5mg
Price
$96
Updated
2023/01/06
American Custom Chemicals Corporation
Product number
API0001795
Product name
BUTORPHANOL TARTRATE
Purity
95.00%
Packaging
1MG
Price
$590.61
Updated
2021/12/16
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Butorphanol tartrate Chemical Properties,Usage,Production

Description

Butorphanol (tartrate) (Item No. 23812) is an analytical reference material categorized as an opioid. Butorphanol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Uses

Analgesic; antitussive.

Definition

ChEBI: The (S,S)-tartaric acid salt of butorphanol. It is used for relief or moderate to severe pain.

brand name

Stadol (Bristol-Myers Squibb).

Biochem/physiol Actions

κ/μ opioid receptor agonist.

Mechanism of action

Butorphanol is a strong agonist at κ opioid receptors, and through this interaction, it is five times more potent than morphine as an analgesic. The κagonists have a lower ceiling analgesic effect than full μ agonists; thus, they are not as effective in treating severe pain. Butorphanol is an antagonist at μ opioid receptors with approximately one-sixth the potency of naloxone. If given to a person addicted to a μ agonist, butorphanol will induce an immediate onset of abstinence syndrome.

Side effects

Butorphanol has a different spectrum of side effects than μ opioid analgesics. Respiratory depression occurs. There is a lower ceiling on this effect, however, and it is not generally lethal, as is the case with high doses of μ agonists. Major side effects after normal analgesic doses are sedation, nausea, and sweating, as well as dysphoric (hallucinogenic) effects at higher doses. Butorphanol causes an increase in pulmonary arterial pressure and pulmonary vascular resistance. There is an overall increased workload on the heart, and it should not be used in patients with congestive heart failure or to treat pain from acute myocardial infarction. Butorphanol has low abuse potential and is not a scheduled drug.

Veterinary Drugs and Treatments

Approved indication for dogs is “. . . for the relief of chronic nonproductive cough associated with tracheobronchitis, tracheitis, tonsillitis, laryngitis and pharyngitis originating from inflammatory conditions of the upper respiratory tract” (Package Insert; Torbutrol?—Fort Dodge). It is also used in practice in both dogs and cats as a preanesthetic medication, analgesic, and as an antiemetic prior to cisplatin treatment (although not very effective in cats for this indication). Compared with other opiate analgesics, butorphanol is not very useful in small animals (particularly dogs) for treating pain and has to be dosed frequently.
The approved indication for horses is “. . . for the relief of pain associated with colic in adult horses and yearlings” (Package Insert; Torbugesic?—Fort Dodge). It has also been used clinically as an analgesic in cattle.

Butorphanol tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Butorphanol tartrate Suppliers

Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9824
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9666
Advantage
60
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4528
Advantage
56
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51022
Advantage
80
Baoji Guokang Healthchem co.,ltd
Tel
+8615604608665 15604608665
Email
dominicguo@gk-bio.com
Country
CHINA
ProdList
9437
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23931
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+undefined-86-13650506873 +undefined-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39915
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
47427
Advantage
58
Zhuozhou Wenxi import and Export Co., Ltd
Tel
+8613111626072
Fax
Wechat: +8613111626072 Wickr me: waynehu
Email
zzwenxi@126.com
Country
CHINA
ProdList
13170
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
021-021-54890099
Email
shanpel@anpel.com.cn
Country
China
ProdList
8502
Advantage
58
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View Lastest Price from Butorphanol tartrate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Butorphanol tartrate 58786-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Butorphanol tartrate 58786-99-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-10

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