tert-butyl 4-hydroxybenzoate
Uses- Product Name
- tert-butyl 4-hydroxybenzoate
- CAS No.
- 25804-49-3
- Chemical Name
- tert-butyl 4-hydroxybenzoate
- Synonyms
- tert-Butyl p-hydroxybenzoate;tert-butyl 4-hydroxybenzoate;1,1-Dimethylethyl 4-hydroxybenzoate;p-Hydroxybenzoic acid tert-butyl ester;4-Hydroxy-benzoic acid tert-butyl ester;4-Hydroxybenzoic acid 1,1-dimethylethyl ester;Benzoic acid, 4-hydroxy-, 1,1-diMethylethyl ester
- CBNumber
- CB4935199
- Molecular Formula
- C11H14O3
- Formula Weight
- 194.23
- MOL File
- 25804-49-3.mol
tert-butyl 4-hydroxybenzoate Property
- Melting point:
- 130-132 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
- Boiling point:
- 295.6±13.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 8.25±0.15(Predicted)
- color
- White
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135775
- Product name
- tert-Butyl4-Hydroxybenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0385389
- Product name
- TERT-BUTYL-4-HYDROXYBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.33
- Updated
- 2021/12/16
- Product number
- J93192
- Product name
- tert-Butyl4-hydroxybenzoate
- Packaging
- 100g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- A432876
- Product name
- tert-Butyl4-hydroxybenzoate
- Purity
- 96%
- Packaging
- 250mg
- Price
- $5
- Updated
- 2021/12/16
- Product number
- A432876
- Product name
- tert-Butyl4-hydroxybenzoate
- Purity
- 96%
- Packaging
- 1g
- Price
- $7
- Updated
- 2021/12/16
tert-butyl 4-hydroxybenzoate Chemical Properties,Usage,Production
Uses
4-Hydroxybenzoate tert-butyl ester is used in organic synthesis, biochemical research, etc.
Synthesis
75-65-0
99-96-7
25804-49-3
Using p-hydroxybenzoic acid (1.50 g, 10.86 mmol) and tert-butanol (13.34 g, 18 mmol) as raw materials, DCC (2.5 g, 12.00 mmol) was dissolved in DCM (40 mL) catalyzed by DBU (0.19 mL, 1.20 mmol), and the reaction mixture was stirred vigorously for 18 hours at room temperature. After completion of the reaction, the solvent was evaporated to dryness and the residue was dissolved in DCM (50 mL) and filtered to remove insoluble material. The filtrate was washed sequentially with saturated NaHCO3 solution (50 mL), K2CO3 solution (2 x 50 mL) and saturated NaCl solution (50 mL). The organic phase was dried with MgSO4, filtered and the solvent was evaporated to give the crude product. The crude product was purified by column chromatography (EtOAc:hexane gradient elution) to afford tert-butyl 4-hydroxybenzoate (SO2-059) (31) as a white crystalline solid (1.1 g, 55% yield).1H NMR (400 MHz, CDCl3) δ 7.89 (d, J = 8.8 Hz, 1H), 6.84 (d, J = 8.9 Hz, 1H) 5.29 (s, 1H), 1.57 (s, 9H).
References
[1] Journal of Materials Chemistry, 2007, vol. 17, # 48, p. 5097 - 5110
[2] Synthesis, 2003, # 16, p. 2479 - 2482
[3] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 716 - 735
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3645 - 3649
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 10, p. 3783 - 3805
tert-butyl 4-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-butyl 4-hydroxybenzoate manufacturers
- Product
- tert-butyl 4-hydroxybenzoate 25804-49-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09