ChemicalBook > CAS DataBase List > (±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

Product Name
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
CAS No.
60398-91-6
Chemical Name
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
Synonyms
Einecs 262-216-3;KJBONRGCLLBWCJ-UHFFFAOYSA-O;Bufuralol hydrochloride (Ro 3-4787);α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride;(1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride
CBNumber
CB4939096
Molecular Formula
C16H24ClNO2
Formula Weight
297.82026
MOL File
60398-91-6.mol
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(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Property

Melting point:
143-146 °C
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
UC168
Product name
(±)-Bufuralol hydrochloride
Packaging
5mg
Price
$1440
Updated
2024/03/01
Sigma-Aldrich
Product number
UC168
Product name
(±)-Bufuralol hydrochloride
Packaging
10mg
Price
$2550
Updated
2024/03/01
Cayman Chemical
Product number
17794
Product name
Bufuralol (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
17794
Product name
Bufuralol (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
17794
Product name
Bufuralol (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$505
Updated
2024/03/01
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(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Chemical Properties,Usage,Production

Description

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

Uses

A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.

Uses

CYP2D6 substrate

Biochem/physiol Actions

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.

in vitro

Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.

in vivo

Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers.

References

[1] fothergill ga, francis rj, hamilton tc, osbond jm, parkes mw. bufuralol, a new beta-adrenoceptor blocking agent. experientia. 1975 nov 15;31(11):1322-3.
[2] pringle, t. h.,francis, r.j.,east, p.b., et al. pharmacodynamic and pharmacokinetic studies on bufuralol in man. br.j.clin.pharmac. 22, 527-534 (1986).

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Suppliers

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60398-91-6, (±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochlorideRelated Search:


  • (1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride
  • α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
  • Einecs 262-216-3
  • KJBONRGCLLBWCJ-UHFFFAOYSA-O
  • Bufuralol hydrochloride (Ro 3-4787)
  • 60398-91-6
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals