1-Cyclopropylpiperazine

Product Name: 1-Cyclopropylpiperazine
CAS No.: 20327-23-5
Chemical Name: 1-Cyclopropylpiperazine
Synonyms: Cyclopropyl piperazine;N-cyclopropylpiperazine;1-Cyclopropylpiperazine;Piperazine,1-cyclopropyl-;1-Cyclopropylpiperazine >(Piperazin-1-yl)cyclopropane;1-(Cyclopropyl Phenyl)Piperazine;1-Cyclopropylpiperazine - [C14363];1-Cyclopropylpiperazine ISO 9001：2015 REACH
CBNumber: CB4947000
Molecular Formula: C7H14N2
Formula Weight: 126.2
MOL File: 20327-23-5.mol

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1-Cyclopropylpiperazine Property

Boiling point:: 43°C/7mm
Density: 0.94
refractive index: 1.4804
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
pka: 9.23±0.10(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2
InChIKey: HNZJIWIXRPBFAN-UHFFFAOYSA-N
SMILES: N1(C2CC2)CCNCC1

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Safety

Hazard Codes: Xi
RIDADR: 3267
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2794
Product name: 1-Cyclopropylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $154
Updated: 2025/07/31

TRC

Product number: C986860
Product name: 1-Cyclopropylpiperazine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC75911
Product name: 1-Cyclopropylpiperazine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: OR15663
Product name: 1-Cyclopropylpiperazine
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-U6
Product name: 1-Cyclopropylpiperazine
Packaging: 1g
Price: $77
Updated: 2021/12/16

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1-Cyclopropylpiperazine Chemical Properties,Usage,Production

Uses

1-cyclopropylpiperazine is a piperazine derivative known in the literature by synonyms such as N-cyclopropylpiperazine and 4-cyclopropylpiperazine. It has been used in the preparation of some tri- and tetrasubstituted ureas with histamine H3 antagonist receptor activity, 3-amido-4- anilinoquinolines series as CSF-1R kinase inhibitors, for the synthesis of cyclopropyl amines as modulators of the histamine H3 receptor, sulfonamide compounds as cysteine protease inhibitors, N-oxides as antibacterial agents and in the treatment of the disease caused by helicobacter infection[1].

Synthesis

77278-34-3

20327-23-5

Tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) was used as a raw material, which was dissolved in a 1,4-dioxane solution (4.37 mL, 17.50 mmol) in 4 M HCl. The reaction mixture was stirred at room temperature for 3 hours under nitrogen protection. Upon completion of the reaction, the mixture was filtered and washed with ether to afford the crude product 1-cyclopropylpiperazine (0.659 g) as a white solid. Subsequently, the crude product was purified by ion exchange chromatography through SCX column. The target compound 1-cyclopropylpiperazine was eluted from the column using 3.5 M NH3/MeOH solution, and the pure grades were collected and evaporated to dryness to give the final 1-cyclopropylpiperazine (0.264 g, 59.7% yield) as a yellow oil. The structure of the product was confirmed by 1H NMR (399.9 MHz, DMSO-d6) with chemical shifts δ 0.25-0.30 (2H, m), 0.35-0.40 (2H, m), 1.54-1.60 (1H, m), 2.43 (4H, t), 2.60-2.65 (4H, t), 3.30 (1H, s).

References

[1] G. Ke?an. “DFT, FT-Raman, and FT-IR investigations of 1-cyclopropylpiperazine.” Journal of Structural Chemistry 54 6 (2014): 1044–1054.

1-Cyclopropylpiperazine Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 1-Cyclopropylpiperazine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Cyclopropylpiperazine 20327-23-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-08

Dideu Industries Group Limited

Product: 1-Cyclopropylpiperazine 20327-23-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-24

Career Henan Chemical Co

Product: 1-Cyclopropylpiperazine 20327-23-5
Price: US $3.00/ASSAYS
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

20327-23-5, 1-Cyclopropylpiperazine Related Search:

1-Cyclopropylpiperazine Ciclofenazine 1-CYCLOPROPYLPIPERAZINE DIHYDROCHLORIDE 4-[(4-CYCLOPROPYLPIPERAZIN-1-YL)SULFONYL]ANILINE AKOS BB-5639 AKOS BB-5641 AKOS BB-5642 AKOS BB-5629 AKOS BB-5640 AKOS BB-5643 AKOS BB-5628 AKOS BB-5626 AKOS BB-5637 AKOS BB-5645 AKOS BB-5630 AKOS BB-5638 AKOS BB-5625 AKOS BB-5631

1-Cyclopropylpiperazine

(Piperazin-1-yl)cyclopropane

N-cyclopropylpiperazine

Cyclopropyl piperazine

Piperazine,1-cyclopropyl-

1-Cyclopropylpiperazine &gt

1-Cyclopropylpiperazine ISO 9001：2015 REACH

1-(Cyclopropyl Phenyl)Piperazine

1-Cyclopropylpiperazine - [C14363]

20327-23-5

20327-32-5

Piperazines

Pyridines