7-Fluoro-1-indanone

Product Name: 7-Fluoro-1-indanone
CAS No.: 651735-59-0
Chemical Name: 7-Fluoro-1-indanone
Synonyms: 7-fluoro-2,3-dihydro-1H-inden-1-one;7-Fluorindan-1-on;7-FLUORO-1-INDANONE;7-fluoro-2,3-dihydroinden-1-one;1H-Inden-1-one,7-fluoro-2,3-dihydro-;1H-Inden-1-one,7-fluoro-2,3-dihydro-(9CI);2,3-Dihydro-7-fluoro-1H-inden-1-one, 2,3-Dihydro-7-fluoro-1-oxo-1H-indene
CBNumber: CB4948067
Molecular Formula: C9H7FO
Formula Weight: 150.15
MOL File: 651735-59-0.mol

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7-Fluoro-1-indanone Property

Boiling point:: 245.1±29.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C9H7FO/c10-7-3-1-2-6-4-5-8(11)9(6)7/h1-3H,4-5H2
InChIKey: ASSCRDJQEHFKSX-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2F)CC1

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Safety

HS Code: 2914390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B434803
Product name: 7-Fluoro-2,3-dihydroinden-1-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0006854
Product name: 7-FLUOROINDAN-1-ONE
Purity: 95.00%
Packaging: 1G
Price: $241.5
Updated: 2021/12/16

AK Scientific

Product number: W7651
Product name: 7-fluoro-2,3-dihydro-1H-inden-1-one
Packaging: 5g
Price: $300
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-3-Z6
Product name: 7-Fluoroindan-1-one
Packaging: 1g
Price: $186
Updated: 2021/12/16

Matrix Scientific

Product number: 073605
Product name: 7-Fluoro-2,3-dihydroinden-1-one
Purity: 95+%
Packaging: 1g
Price: $416
Updated: 2021/12/16

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7-Fluoro-1-indanone Chemical Properties,Usage,Production

Synthesis

898767-04-9

651735-59-0

The general procedure for the synthesis of 7-fluoro-1-indanone from 3-chloro-1-(2-fluorophenyl)propan-1-one is as follows: first, a mixture of SOCl2 (1.5 equiv.) and substituted benzoic acid in benzene is refluxed until no gas escapes. After cooling to room temperature, the mixture was concentrated using a rotary evaporator. The concentrate was dissolved in dichloroethane and a dichloroethane solution of AlCl3 (1.0 eq.) was slowly added at 10-20 °C. Subsequently, ethylene gas was passed into the reaction system for 4 hours, after which the mixture was stirred overnight and the reaction was quenched with 4N HCl. The organic and aqueous layers were separated and the aqueous layer was extracted with Et2O (3 x 250 mL). The organic extracts were combined and washed sequentially with H2O (3 × 150 mL), saturated NaHCO3 (3 × 150 mL) and brine (1 × 150 mL), dried over MgSO4 and concentrated. The concentrate was mixed with a slurry of AlCl3 (9.0 g, 10 eq.) and NaCl (2.4 g, 6 eq.) and stirred at 180 °C for 2 hours. Alternatively, the concentrate was mixed with concentrated sulfuric acid and stirred at 85°C for 1 hour. Upon completion of the reaction, it was cooled to room temperature and ice was slowly added, followed by the addition of concentrated HCl. The reaction mixture was extracted with CH2Cl2 (3 x 500 mL), the organic layers were combined and concentrated, and finally the target product 7-fluoro-1-indanone was purified by column chromatography using hexanes:EtOAc (4:1) as eluent to give the target product 7-fluoro-1-indanone. 1-(2-fluoroethyl)-3-(7-fluoroindan-1-yl)urea was further synthesized from 7-fluoro-1-indanone according to General Method C. The title compound was prepared from commercially available 2-fluorobenzoic acid by General Method E described above. The intermediates 7-fluoro-1-indanone and 7-fluoroindan-1-ylamine were isolated and characterized. 7-fluoro-1-indanone was prepared in 32% yield (6.85 g from 20.00 g, 0.14 mol of 2-fluorobenzoic acid) using SOCl2 (15.60 mL, 0.21 mol), AlCl3 (19.00 g, 0.14 mol), additional AlCl3 (285.50 g, 2.14 mol) and NaCl (75.10 g, 1.29 mol). The spectral data were as follows: 1H NMR (300 MHz, CDCl3) δ 2.67-2.80 (m, 2H), 3.2 (t, 2H, J = 5.9 Hz), 7.0 (t, 1H, J = 8.5 Hz), 7.3 (d, 1H, J = 7.6 Hz), 7.6 (m, 1H).

References

[1] Patent: US2008/255239, 2008, A1. Location in patent: Page/Page column 22; 23
[2] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10195 - 10198

7-Fluoro-1-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Fluoro-1-indanone Suppliers

Austria 1 Canada 1 China 120 Europe 1 Germany 1 India 1 United Kingdom 1 United States 12 Global 138

Suzhou ChonTech Biopharma Co.,Ltd

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DILICHEM

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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Chembest Research Laboratories Limited

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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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China DongFan Chemical Co.,LTD

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PSN Pharmaceutical Technology Co., Ltd.

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View Lastest Price from 7-Fluoro-1-indanone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 7-Fluorindan-1-on 651735-59-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-07

Henan Aochuang Chemical Co.,Ltd.

Product: 7-Fluoro-1-indanone 651735-59-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: 7-Fluoro-1-indanone 651735-59-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

651735-59-0, 7-Fluoro-1-indanoneRelated Search:

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1H-Inden-1-one,7-fluoro-2,3-dihydro-(9CI)

7-fluoro-2,3-dihydroinden-1-one

7-fluoro-2,3-dihydro-1H-inden-1-one

2,3-Dihydro-7-fluoro-1H-inden-1-one, 2,3-Dihydro-7-fluoro-1-oxo-1H-indene

1H-Inden-1-one,7-fluoro-2,3-dihydro-

7-FLUORO-1-INDANONE

7-Fluorindan-1-on

651735-59-0

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