6-Fluoro-1-indanone

Product Name: 6-Fluoro-1-indanone
CAS No.: 1481-32-9
Chemical Name: 6-Fluoro-1-indanone
Synonyms: 6-Fluoro-2,3-dihydro-1H-inden-1-one;6-FLUOROINDANONE;6-fluro-indanone;6-Fluorindan-1-on;6-Fluoro-indan-1-on;6-FLUORO-1-INDANONE;6-Fluoro-1-indenone;6-FLURORO-1-INDANONE;6-FLUORO-INDAN-1-ONE;6-FLUORORO-1-INDANONE
CBNumber: CB0196811
Molecular Formula: C9H7FO
Formula Weight: 150.15
MOL File: 1481-32-9.mol

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6-Fluoro-1-indanone Property

Melting point:: 56-60 °C
Boiling point:: 60 °C/0.07kPa
Density: 1.259±0.06 g/cm3(Predicted)
Flash point:: 60°C/0.5mm
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystalline Powder
color: Off-white to pale brown
BRN: 1448695
InChI: InChI=1S/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2
InChIKey: LVUUCFIQQHEFEJ-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC(F)=C2)CC1
CAS DataBase Reference: 1481-32-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-37
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 663123
Product name: 6-Fluoro-1-indanone
Purity: 96%
Packaging: 5g
Price: $559
Updated: 2023/06/20

Sigma-Aldrich

Product number: 663123
Product name: 6-Fluoro-1-indanone
Purity: 96%
Packaging: 1g
Price: $98
Updated: 2022/05/15

TCI Chemical

Product number: F0668
Product name: 6-Fluoro-1-indanone
Purity: >98.0%(GC)
Packaging: 1g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: F0668
Product name: 6-Fluoro-1-indanone
Purity: >98.0%(GC)
Packaging: 5g
Price: $249
Updated: 2025/07/31

TRC

Product number: F595423
Product name: 6-Fluoro-2,3-dihydro-1H-inden-1-one
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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6-Fluoro-1-indanone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

6-Fluoro-1-indanone is an intermediate compound that can be used as an organic synthesis raw material for the preparation of pharmaceutical and chemical products. It is also an excellent reaction reagent that can undergo various chemical reactions, including oxidation, reduction and substitution.

Synthesis

772-70-3

1481-32-9

The general procedure for the synthesis of 6-fluoro-1-indanone from 4-fluoro-benzenepropanoyl chloride was as follows: aluminum trichloride (AlCl3, 27.8 g, 208 mmol) was suspended in 200 mL of 1,2-dichloroethane. The mixture was cooled to 0-5 °C under nitrogen protection and a solution of 4-fluoro-phenylpropionyl chloride (27.75 g, 148.8 mmol) dissolved in 140 mL of 1,2-dichloroethane was added slowly and dropwise over a period of 1 hour. After removal of the cooling bath, stirring was continued for 30 minutes, followed by 2 hours of reaction at 70°C. Upon completion of the reaction, the mixture was cooled to room temperature and poured into a mixture of ice and 330 mL of concentrated hydrochloric acid (36-38%). The aqueous layer was extracted with dichloromethane (CH2Cl2) and the combined organic layers were washed sequentially with water (2×), 5% sodium bicarbonate (NaHCO3) solution and saturated saline. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered to remove the desiccant, and the solvent was evaporated under reduced pressure to give 19.02 g of 6-fluoro-1-indanone in 85% yield.

References

[1] Patent: US2006/122189, 2006, A1. Location in patent: Page/Page column 27
[2] Bulletin de la Societe Chimique de France, 1973, p. 3092 - 3095
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 399 - 408
[4] European Journal of Organic Chemistry, 2007, # 18, p. 2987 - 2994
[5] Patent: US5872118, 1999, A

6-Fluoro-1-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Fluoro-1-indanone Suppliers

Americas 1 Austria 1 China 168 Europe 3 Germany 7 India 13 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 18 United States 45 Global 260

Suzhou Liyuan Biomedical Technology Co., Ltd.

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INTATRADE GmbH

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Energy Chemical

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View Lastest Price from 6-Fluoro-1-indanone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 6-Fluoro-1-indanone 1481-32-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-11-11

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Fluoro-1-indanone 1481-32-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Fluoro-1-indanone 1481-32-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-14

1481-32-9, 6-Fluoro-1-indanoneRelated Search:

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6-FLUORORO-1-INDANONE

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6-Fluoro-1-indanone&gt

6-Fluorindan-1-on

tert-butyl 3-(1-amino-2,2,2-trifluoroethyl)-5-bromobenzoate

1481-32-9

C9H7FO

Ketones

Organic Building Blocks

C9

Carbonyl Compounds

Building Blocks

Indane/Indanone and Derivatives

pharmacetical

Indanone & Indene