ChemicalBook > CAS DataBase List > 6-Fluoro-1-indanone
6-Fluoro-1-indanone
- Product Name
- 6-Fluoro-1-indanone
- CAS No.
- 1481-32-9
- Chemical Name
- 6-Fluoro-1-indanone
- Synonyms
- 6-Fluoro-2,3-dihydro-1H-inden-1-one;6-FLUOROINDANONE;6-fluro-indanone;6-Fluorindan-1-on;6-Fluoro-indan-1-on;6-FLUORO-1-INDANONE;6-Fluoro-1-indenone;6-FLURORO-1-INDANONE;6-FLUORO-INDAN-1-ONE;6-FLUORORO-1-INDANONE
- CBNumber
- CB0196811
- Molecular Formula
- C9H7FO
- Formula Weight
- 150.15
- MOL File
- 1481-32-9.mol
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6-Fluoro-1-indanone Property
- Melting point:
- 56-60 °C
- Boiling point:
- 60 °C/0.07kPa
- Density
- 1.259±0.06 g/cm3(Predicted)
- Flash point:
- 60°C/0.5mm
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- color
- Off-white to pale brown
- BRN
- 1448695
- InChI
- InChI=1S/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2
- InChIKey
- LVUUCFIQQHEFEJ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(F)=C2)CC1
- CAS DataBase Reference
- 1481-32-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37
- WGK Germany
- 2
- HazardClass
- IRRITANT
- HS Code
- 29147000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 663123
- Product name
- 6-Fluoro-1-indanone
- Purity
- 96%
- Packaging
- 5g
- Price
- $559
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 663123
- Product name
- 6-Fluoro-1-indanone
- Purity
- 96%
- Packaging
- 1g
- Price
- $98
- Updated
- 2022/05/15
TCI Chemical
- Product number
- F0668
- Product name
- 6-Fluoro-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0668
- Product name
- 6-Fluoro-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $249
- Updated
- 2025/07/31
TRC
- Product number
- F595423
- Product name
- 6-Fluoro-2,3-dihydro-1H-inden-1-one
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
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6-Fluoro-1-indanone Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
6-Fluoro-1-indanone is an intermediate compound that can be used as an organic synthesis raw material for the preparation of pharmaceutical and chemical products. It is also an excellent reaction reagent that can undergo various chemical reactions, including oxidation, reduction and substitution.
Synthesis
772-70-3
1481-32-9
The general procedure for the synthesis of 6-fluoro-1-indanone from 4-fluoro-benzenepropanoyl chloride was as follows: aluminum trichloride (AlCl3, 27.8 g, 208 mmol) was suspended in 200 mL of 1,2-dichloroethane. The mixture was cooled to 0-5 °C under nitrogen protection and a solution of 4-fluoro-phenylpropionyl chloride (27.75 g, 148.8 mmol) dissolved in 140 mL of 1,2-dichloroethane was added slowly and dropwise over a period of 1 hour. After removal of the cooling bath, stirring was continued for 30 minutes, followed by 2 hours of reaction at 70°C. Upon completion of the reaction, the mixture was cooled to room temperature and poured into a mixture of ice and 330 mL of concentrated hydrochloric acid (36-38%). The aqueous layer was extracted with dichloromethane (CH2Cl2) and the combined organic layers were washed sequentially with water (2×), 5% sodium bicarbonate (NaHCO3) solution and saturated saline. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered to remove the desiccant, and the solvent was evaporated under reduced pressure to give 19.02 g of 6-fluoro-1-indanone in 85% yield.
References
[1] Patent: US2006/122189, 2006, A1. Location in patent: Page/Page column 27
[2] Bulletin de la Societe Chimique de France, 1973, p. 3092 - 3095
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 399 - 408
[4] European Journal of Organic Chemistry, 2007, # 18, p. 2987 - 2994
[5] Patent: US5872118, 1999, A
6-Fluoro-1-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Fluoro-1-indanone manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 6-Fluoro-1-indanone 1481-32-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-11
Henan Aochuang Chemical Co.,Ltd.
- Product
- 6-Fluoro-1-indanone 1481-32-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 6-Fluoro-1-indanone 1481-32-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2025-03-14
1481-32-9, 6-Fluoro-1-indanoneRelated Search:
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