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ChemicalBook > CAS DataBase List > 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

Uses
Product Name
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
CAS No.
221198-99-8
Chemical Name
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
Synonyms
3-fluoro-4-(4-methyl-1-pi...;3-Fluoro-4-(4-Methyl-1-piperazinyl)aniline;3-Fluoro-4-(4-methylpiperazin-1-yl)aniline;1-(4-Amino-2-fluorophenyl)-4-methylpiperazine;3-fluoro-4-(4-Methyl-1-piperazinyl)benzenaMine;3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamine;Benzenamine, 3-fluoro-4-(4-methyl-1-piperazinyl)-;[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine dihydrochloride
CBNumber
CB4956516
Molecular Formula
C11H16FN3
Formula Weight
209.26
MOL File
221198-99-8.mol
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3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Property

Melting point:
87-89
Boiling point:
349.5±42.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
7.56±0.42(Predicted)
Appearance
Light brown to brown Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

TRC
Product number
F593380
Product name
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
F593380
Product name
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
045112
Product name
3-Fluoro-4-(4-methylpiperazino)aniline
Purity
>95%
Packaging
500mg
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
045112
Product name
3-Fluoro-4-(4-methylpiperazino)aniline
Purity
>95%
Packaging
1g
Price
$24
Updated
2021/12/16
ChemScene
Product number
CS-W021915
Product name
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
Purity
99.19%
Packaging
5g
Price
$55
Updated
2021/12/16
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3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Chemical Properties,Usage,Production

Uses

3-Fluoro-4-(4-methylpiperazinyl)aniline can be used as a pharmaceutical synthesis intermediate.

Synthesis

221198-29-4

221198-99-8

General procedure: 1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine (14.76 g, 61.70 mmol) was dissolved in tetrahydrofuran (THF, 80 mL) and palladium/carbon catalyst (Pd/C, 3.00 g) was added. Hydrogen (H2) was passed into the reaction mixture at room temperature and the reaction was stirred overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 3-fluoro-4-(4-methylpiperazinyl)aniline as an off-white solid (11.99 g, 93% yield).

References

[1] Patent: US2002/151554, 2002, A1
[2] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00293
[3] Patent: US2015/87639, 2015, A1. Location in patent: Paragraph 0550
[4] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 128
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3507 - 3525

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline manufacturers

Career Henan Chemical Co
Product
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 221198-99-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

221198-99-8, 3-Fluoro-4-(4-methylpiperazin-1-yl)anilineRelated Search:

eperezolid N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-4-METHYLBENZENECARBOXAMIDE 2-[(2,4-DIMETHYLPHENYL)SULFANYL]-N-[3-FLUORO-4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE 4-FLUORO-N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]BENZENECARBOXAMIDE 2-[(4-CHLOROPHENYL)SULFANYL]-N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]ACETAMIDE 2-[(4-CHLOROPHENYL)SULFANYL]-N-[3-FLUORO-4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE N-[3-FLUORO-4-(4-METHYLPIPERAZINO)PHENYL]-2-[(4-METHOXYPHENYL)SULFANYL]ACETAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-2-PHENYLACETAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-2-[(4-METHOXYPHENYL)SULFANYL]ACETAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-4-METHOXYBENZENECARBOXAMIDE 3-FLUORO-4-(4-PHENYLPIPERAZINO)ANILINE N-[3-FLUORO-4-(4-METHYLPIPERAZINO)PHENYL]CYCLOPROPANECARBOXAMIDE N-[3-FLUORO-4-(4-METHYLPIPERAZINO)PHENYL]-3-METHYLBENZENECARBOXAMIDE 4-CHLORO-N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]BENZENECARBOXAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-3-METHYLBENZENECARBOXAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]-2-(PHENYLSULFANYL)ACETAMIDE N-[3-FLUORO-4-(4-PHENYLPIPERAZINO)PHENYL]CYCLOPROPANECARBOXAMIDE

  • 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
  • 3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamine
  • 3-fluoro-4-(4-methyl-1-pi...
  • 3-fluoro-4-(4-Methyl-1-piperazinyl)benzenaMine
  • 3-Fluoro-4-(4-Methyl-1-piperazinyl)aniline
  • [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine dihydrochloride
  • 1-(4-Amino-2-fluorophenyl)-4-methylpiperazine
  • Benzenamine, 3-fluoro-4-(4-methyl-1-piperazinyl)-
  • 221198-99-8
  • C11H16FN3