eperezolid

Product Name: eperezolid
CAS No.: 165800-04-4
Chemical Name: eperezolid
Synonyms: U 100592;PNU 100592;eperezolid;Eperezolid-d3;Eperezolid (PNU-100592;PNU-100592;PNU100592;U-100592;PNU-100592; PNU100592; PNU 100592;Bacterial,PNU100592,Inhibitor,inhibit,Eperezolid,PNU 100592,Antibiotic;(S)-N-[[3-[3-Fluoro-4-[4-(hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CBNumber: CB71074285
Molecular Formula: C18H23FN4O5
Formula Weight: 394.4
MOL File: 165800-04-4.mol

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eperezolid Property

Melting point:: 174-176℃
Boiling point:: 701.2±60.0 °C(Predicted)
Density: 1.370±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.05 mg/mL in DMSO
form: Powder
pka: 13.84±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E565742
Product name: Eperezolid-d3
Packaging: 1mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-2793
Product name: Eperezolid
Purity: 96.23%
Packaging: 5mg
Price: $348
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0136369
Product name: ACETAMIDE, N-[[(5S)-3-[3-FLUORO-4-[4-(2-HYDROXYACETYL)-1-PIPERAZINYL]PHENYL]-2-OXO-5-OXAZOLIDINYL]METHYL]-
Purity: 95.00%
Packaging: 5MG
Price: $499.75
Updated: 2021/12/16

ChemScene

Product number: CS-2793
Product name: Eperezolid
Purity: 96.23%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611774
Product name: Eperezolid
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

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eperezolid Chemical Properties,Usage,Production

Uses

Antibacterial.

Uses

Eperezolid is an antimicrobial.

Biological Activity

mic50: 0.5, 1.0, 2.0, 1.0, 16.0 and 2.0 mg/l for pcptostreptococcus, propionibacterium acnes, ciostridium pefringens, clostridium dijiicile, bactrroidesjagilis, and fusobacterium, respectivleyanaerobic bacteria are a common cause of serious infections. anaerobic species which predominate in clinical infections include the bacteroides fragilis group, clostridium spp. and peptostreptococcus spp. the oxazolidinones are a novel class of synthetic antimicrobials inhibiting the initiation of protein synthesis. two compounds of this class, eperezolid and linezolid have been shown to inhibit enterococcus faecalis and enterococcus faecium.

in vitro

ninety per cent of all tested propionibacterium acnes (30 strains), peptostreptococccuj spp. (50 strains), c. perjringens (50 strains) and c. dficile (50 strains) were inhibited by <2 mg/l eperezolid. linezolid showed higher activity (mic90 4.0 mg/l) against b. jragilis (100 strains) compared to eperezolid (mic90 16 mg/l) [1].

in vivo

the in vivo effectiveness of eperezolid and linezolid against one strain each of enterococcus faecalis and vancomycin-resistant enterococcus faecium was examined in a rat intraabdominal abscess model. eperezolid was ineffective at doses of 25 mg/kg of body weight twice daily for the reductions in abscess bacterial density for e. faecalis. against e. faecium infections, intravenous eperezolid was effective, reducing densities approximately 2 log10 cfu/g [2].

References

[1] edlund c, oh h, nord ce. in vitro activity of linezolid and eperezolid against anaerobic bacteria. clin microbiol infect. 1999;5(1):51-53.
[2] schülin t, thauvin-eliopoulos c, moellering rc jr, eliopoulos gm. activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to enterococcus faecalis or vancomycin-resistant enterococcus faecium. antimicrob agents chemother. 1999;43(12):2873-6.
[3] schaadt rd, batts dh, daley-yates pt, pawsey sd, stalker dj, zurenko ge. serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid. diagn microbiol infect dis. 1997;28(4):201-4.

eperezolid Preparation Products And Raw materials

Raw materials

Preparation Products

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eperezolid Suppliers

China 54 Germany 1 India 1 United Kingdom 1 United States 14 Global 71

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1987
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7978
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 5004
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 10200
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

165800-04-4, eperezolidRelated Search:

Ethambutol diHCl Ethyl 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropane-1-carboxylate 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE 2-FLUORO-BENZENE-1,4-DIAMINE (S)-N-[[3-(3-Fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol ETHYL (4-AMINOPHENYL)CARBAMATE N1,N1-DIETHYL-2-FLUORO-1,4-BENZENEDIAMINE 3-PHENYL-2-OXAZOLIDINONE Dimethyl-(4-piperazin-1-yl-phenyl)-amine 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 2-FLUORO-N1,N1-DIMETHYL-1,4-BENZENEDIAMINE (S)-5-(AMINOMETHYL)-3-(3-FLUOROPHENYL)OXAZOLIDIN-2-ONE eperezolid

eperezolid

N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-Acetamide

PNU 100592

(S)-N-[[3-[3-Fluoro-4-[4-(hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

U 100592

Eperezolid-d3

Eperezolid (PNU-100592

(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

PNU-100592;PNU100592;U-100592

PNU-100592; PNU100592; PNU 100592

Acetamide, N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-

N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Bacterial,PNU100592,Inhibitor,inhibit,Eperezolid,PNU 100592,Antibiotic

165800-04-4

C18H23FN4O5