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3-Aminophenylacetic acid, N-BOC protected

Product Name
3-Aminophenylacetic acid, N-BOC protected
CAS No.
123036-51-1
Chemical Name
3-Aminophenylacetic acid, N-BOC protected
Synonyms
Boc-3-APAC-OH;3-(Boc-aMino)phenylacetic acid;N-BOC-3-AMINOPHENYLACETIC ACID;3-[N-BOC-Amino]benzeneacetic acid;3-Aminophenylacetic acid, N-BOC protected;2-(3-((tert-Butoxycarbonyl)aMino)phenyl)acetic acid;3-[(tert-Butoxycarbonyl)amino]phenylacetic acid 95+%;3-[[(1,1-dimethylethoxy)carbonyl]amino]Benzeneacetic acid;Benzeneacetic acid,3-[[(1,1-diMethylethoxy)carbonyl]aMino]-;2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]acetic acid
CBNumber
CB4956879
Molecular Formula
C13H17NO4
Formula Weight
251.28
MOL File
123036-51-1.mol
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3-Aminophenylacetic acid, N-BOC protected Property

Melting point:
100-102
storage temp. 
2-8°C
form 
solid
color 
Off-white
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B630013
Product name
N-Boc-3-AminophenylaceticAcid
Packaging
500mg
Price
$155
Updated
2021/12/16
Matrix Scientific
Product number
012558
Product name
3-tert-Butoxy carbonylaminophenyl acetic acid
Purity
98%
Packaging
500mg
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB49897
Product name
Boc-3-aminophenylacetic acid
Packaging
500mg
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
012558
Product name
3-tert-Butoxy carbonylaminophenyl acetic acid
Purity
98%
Packaging
1g
Price
$97
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-1-X7
Product name
3-[(tert-Butoxycarbonyl)amino]phenylacetic acid
Packaging
1g
Price
$125
Updated
2021/12/16
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3-Aminophenylacetic acid, N-BOC protected Chemical Properties,Usage,Production

Synthesis

24424-99-5

14338-36-4

123036-51-1

GENERAL STEPS: 3-Aminophenylacetic acid (12.4 g, 26.46 mmol, 1 equiv) was dissolved in a solvent mixture of dioxane (52 mL) and water (52 mL). An aqueous solution of sodium carbonate (2.8 g, 26.42 mmol, 1 equiv) was added to this solution (26 mL) under cooling in an ice bath. Subsequently, di-tert-butyl dicarbonate (Boc2O, 6.24 g, 28.59 mmol, 1.1 eq.) was added all at once and stirred continuously for 4 hours at room temperature. Upon completion of the reaction, the dioxane was removed by distillation under reduced pressure. The aqueous layer was cooled, covered with ethyl acetate and acidified with dilute KHSO4 solution to pH 4. The organic layer was extracted with ethyl acetate and purified by silica gel column chromatography (ethyl acetate was used as the eluent) to afford the target compound, N-Boc-3-aminophenylacetic acid (6.65 g, 85% yield), as a white solid.1H-NMR (300 MHz, CDCl3) data were as follows: δ 7.31 (d, 2H, J = 8.4 Hz), 7.20 (d, 2H, J = 8.4 Hz), 6.56 (br s, 1H), 3.59 (s, 2H), 1.50 (s, 9H).

References

[1] Tetrahedron, 2002, vol. 58, # 43, p. 8695 - 8702
[2] Molecules, 2017, vol. 22, # 1,
[3] Organic and Biomolecular Chemistry, 2018, vol. 16, # 22, p. 4127 - 4140

3-Aminophenylacetic acid, N-BOC protected Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Aminophenylacetic acid, N-BOC protected Suppliers

China 46 India 2 United Kingdom 3 United States 8 Global 59
Accela ChemBio Inc.
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Combi-Blocks Inc.
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SynQuest Laboratories, Inc.
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Matrix Scientific
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123036-51-1, 3-Aminophenylacetic acid, N-BOC protectedRelated Search:

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