3-Ethoxy-4-fluorobenzeneboronic acid
- Product Name
- 3-Ethoxy-4-fluorobenzeneboronic acid
- CAS No.
- 900174-65-4
- Chemical Name
- 3-Ethoxy-4-fluorobenzeneboronic acid
- Synonyms
- 3-Ethoxy-4-fL;5-Borono-2-fluorophenetole;3-Ethoxy-4-fluorophenylboronic acid;3-Ethoxy-4-fluorobenzeneboronic acid;3-Ethoxy-4-fluorobenzeneboronicacid96%;3-Ethoxy-4-fluorobenzeneboronic acid 96%;B-(3-Ethoxy-4-Fluorophenyl)-Boronic Acid;Boronic acid, B-(3-ethoxy-4-fluorophenyl)-;3-Ethoxy-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB4957210
- Molecular Formula
- C8H10BFO3
- Formula Weight
- 183.97
- MOL File
- 900174-65-4.mol
3-Ethoxy-4-fluorobenzeneboronic acid Property
- Boiling point:
- 328.1±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 8.23±0.10(Predicted)
- color
- White to Almost white
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- E1183
- Product name
- 3-Ethoxy-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- E892070
- Product name
- 3-Ethoxy-4-fluorophenylboronicacid
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- PC7571
- Product name
- 3-Ethoxy-4-fluorobenzeneboronicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $97
- Updated
- 2021/12/16
- Product number
- 40215
- Product name
- 3-Ethoxy-4-fluorophenylboronicacid,97-105%(Assaybytitration)
- Purity
- 97-105%(Assaybytitration)
- Packaging
- 1G
- Price
- $100.17
- Updated
- 2021/12/16
- Product number
- 6660-3-N3
- Product name
- 3-Ethoxy-4-fluorobenzeneboronic acid
- Purity
- 96%
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
3-Ethoxy-4-fluorobenzeneboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
900174-64-3
900174-65-4
General procedure for the synthesis of 3-ethoxy-4-fluorophenylboronic acid from 2-fluoro-5-bromophenethyl ether: n-butyllithium (n-BuLi, 1.6 M hexane solution, 14.3 mL, 22.8 mmol) was slowly added to a tetrahydrofuran (THF, 60 mL) solution of 2-fluoro-5-bromophenethyl ether (3.86 g, 17.6 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of trimethyl borate (3.63 mL, 33 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (40 mL) followed by extraction of the organic phase with ethyl acetate (EtOAc). The organic layer was washed with brine and dried with anhydrous sodium sulfate (Na2SO4). After removal of solvent by evaporation under reduced pressure, the crude product was purified by grinding with ethyl acetate/hexane (1:4) solvent mixture. After filtration, the target product 3-ethoxy-4-fluorophenylboronic acid (9B, 2.2 g, 69% yield) was obtained as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.42 (t, J = 7.03 Hz, 3H), 4.11 (q, J = 7.03 Hz, 2H), 7.03 (dd, J = 11.42,8.35 Hz, 1H), 7.18-7.29 (m, 2H), 7.35 (d, J = 7.91 Hz, 1H).
References
[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 29
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 69
3-Ethoxy-4-fluorobenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Ethoxy-4-fluorobenzeneboronic acid Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 3-Ethoxy-4-fluorobenzeneboronic acid manufacturers
- Product
- 3-Ethoxy-4-fluorobenzeneboronic acid 900174-65-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03