4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
- Product Name
- 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
- CAS No.
- 279263-10-4
- Chemical Name
- 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
- Synonyms
- AKOS BRN-0575;4-Ethoxy-3-fL;4-Borono-2-fluorophenetole;4-Ethoxy-3-Fluorophenylboronic;(4-ethyl-2-thiophenyl)boronic acid;4-ETHOXY-3-FLUOROPHENYLBORONIC ACID;3-FLUORO-4-ETHOXYBENZENEBORONIC ACID;4-ETHOXY-3-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(4-ethoxy-3-fluorophenyl)-;4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB6338044
- Molecular Formula
- C8H10BFO3
- Formula Weight
- 183.97
- MOL File
- 279263-10-4.mol
4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Property
- Melting point:
- 108-113 C
- Boiling point:
- 328.1±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 7.90±0.10(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 279263-10-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E1124
- Product name
- 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- E1124
- Product name
- 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- E892093
- Product name
- 4-Ethoxy-3-fluorophenylboronic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- N178
- Product name
- 4-Ethoxy-3-fluorophenylboronic acid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- BOR0001515
- Product name
- 3-FLUORO-4-ETHOXYBENZENEBORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $127.26
- Updated
- 2021/12/16
4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
121-43-7
115467-08-8
279263-10-4
General procedure for the synthesis of 4-ethoxy-3-fluorophenylboronic acid from trimethyl borate and 4-bromo-2-fluorophenylethyl ether: 4-bromo-2-fluorophenylethyl ether (43.8 g) was dissolved in dry tetrahydrofuran (400 ml) and the resulting solution was cooled down to -70 °C. Under nitrogen protection, n-butyllithium (133 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran solution of trimethyl borate (64.8 g) was slowly added at the same temperature. The reaction solution was gradually warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of 2N hydrochloric acid (200 ml) and the reaction mixture was extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene=4:1, v/v) gave colorless crystals of 4-ethoxy-3-fluorophenylboronic acid (23.9 g, yield: 65%).
References
[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 44
4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID manufacturers
- Product
- 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID 279263-10-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03