ChemicalBook > CAS DataBase List > 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID

4-ETHOXY-3-FLUOROPHENYLBORONIC ACID

Product Name: 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
CAS No.: 279263-10-4
Chemical Name: 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
Synonyms: AKOS BRN-0575;4-Ethoxy-3-fL;4-Borono-2-fluorophenetole;4-Ethoxy-3-Fluorophenylboronic;(4-ethyl-2-thiophenyl)boronic acid;4-ETHOXY-3-FLUOROPHENYLBORONIC ACID;3-FLUORO-4-ETHOXYBENZENEBORONIC ACID;4-ETHOXY-3-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(4-ethoxy-3-fluorophenyl)-;4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
CBNumber: CB6338044
Molecular Formula: C8H10BFO3
Formula Weight: 183.97
MOL File: 279263-10-4.mol

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4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Property

Melting point:: 108-113 C
Boiling point:: 328.1±52.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 7.90±0.10(Predicted)
color: White to Almost white
CAS DataBase Reference: 279263-10-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1124
Product name: 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: E1124
Product name: 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $78
Updated: 2025/07/31

TRC

Product number: E892093
Product name: 4-Ethoxy-3-fluorophenylboronic acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: N178
Product name: 4-Ethoxy-3-fluorophenylboronic acid
Packaging: 1g
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0001515
Product name: 3-FLUORO-4-ETHOXYBENZENEBORONIC ACID
Purity: 95.00%
Packaging: 1G
Price: $127.26
Updated: 2021/12/16

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4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

121-43-7

115467-08-8

279263-10-4

General procedure for the synthesis of 4-ethoxy-3-fluorophenylboronic acid from trimethyl borate and 4-bromo-2-fluorophenylethyl ether: 4-bromo-2-fluorophenylethyl ether (43.8 g) was dissolved in dry tetrahydrofuran (400 ml) and the resulting solution was cooled down to -70 °C. Under nitrogen protection, n-butyllithium (133 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran solution of trimethyl borate (64.8 g) was slowly added at the same temperature. The reaction solution was gradually warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of 2N hydrochloric acid (200 ml) and the reaction mixture was extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene=4:1, v/v) gave colorless crystals of 4-ethoxy-3-fluorophenylboronic acid (23.9 g, yield: 65%).

References

[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 44

4-ETHOXY-3-FLUOROPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID manufacturers

Career Henan Chemical Co

Product: 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID 279263-10-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg; 5kg; 100kg
Release date: 2019-07-03

279263-10-4, 4-ETHOXY-3-FLUOROPHENYLBORONIC ACIDRelated Search:

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AKOS BRN-0575

4-ETHOXY-3-FLUOROBENZENEBORONIC ACID

4-ETHOXY-3-FLUOROPHENYLBORONIC ACID

3-FLUORO-4-ETHOXYBENZENEBORONIC ACID

4-Ethoxy-3-Fluorophenylboronic

4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)

4-Borono-2-fluorophenetole

(4-ethyl-2-thiophenyl)boronic acid

4-Ethoxy-3-fL

Boronic acid, B-(4-ethoxy-3-fluorophenyl)-

279263-10-4

C2H5OC6H3FBOH2

C8H10BFO3

Organometallic Reagents

Aryl

Boronic Acids and Derivatives

Boronic Acids

Aryl

Boronic acid

Organoborons

Boronic Acids

Boronic Acids and Derivatives

Boronic Acids

blocks

BoronicAcids

FluoroCompounds