ChemicalBook > CAS DataBase List > GUVACINE HYDROCHLORIDE

GUVACINE HYDROCHLORIDE

Product Name
GUVACINE HYDROCHLORIDE
CAS No.
6027-91-4
Chemical Name
GUVACINE HYDROCHLORIDE
Synonyms
1,2,5,6-Tetrahydro-;GUVACINE HYDROCHLORIDE;Norareca alkaloid hydrochloride;GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK;Guvacine hydrochloride >=97% (NMR), solid;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
CBNumber
CB4972615
Molecular Formula
C6H10ClNO2
Formula Weight
163.6021
MOL File
6027-91-4.mol
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GUVACINE HYDROCHLORIDE Property

Melting point:
316 °C (decomp)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: soluble
form 
solid
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23361
Product name
Guvacine (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
23361
Product name
Guvacine (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
23361
Product name
Guvacine (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
23361
Product name
Guvacine (hydrochloride)
Purity
≥95%
Packaging
250mg
Price
$437
Updated
2024/03/01
TRC
Product number
G876400
Product name
Guvacine hydrochloride
Packaging
100mg
Price
$200
Updated
2021/12/16
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GUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.

Uses

Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.

Biological Activity

Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

in vitro

Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.

GUVACINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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GUVACINE HYDROCHLORIDE Suppliers

ChengDu YiRui Bio-Technology CO., LTD
Tel
182-24028459 18224018291
Fax
QQ137193152
Email
3004072879@qq.com
Country
China
ProdList
1195
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8878
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
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66
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
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View Lastest Price from GUVACINE HYDROCHLORIDE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
GUVACINE HYDROCHLORIDE 6027-91-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-24

6027-91-4, GUVACINE HYDROCHLORIDERelated Search:


  • GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK
  • 1,2,5,6-Tetrahydro-
  • 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride
  • 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
  • Guvacine hydrochloride >=97% (NMR), solid
  • GUVACINE HYDROCHLORIDE
  • Norareca alkaloid hydrochloride
  • 6027-91-4
  • GABA and Glycine Receptor ModulatorsNeurotransmitters
  • GABAergics
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Others
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  • Heterocycles
  • Intermediates & Fine Chemicals
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