GUVACINE HYDROCHLORIDE
- Product Name
- GUVACINE HYDROCHLORIDE
- CAS No.
- 6027-91-4
- Chemical Name
- GUVACINE HYDROCHLORIDE
- Synonyms
- 1,2,5,6-Tetrahydro-;GUVACINE HYDROCHLORIDE;Norareca alkaloid hydrochloride;GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK;Guvacine hydrochloride >=97% (NMR), solid;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
- CBNumber
- CB4972615
- Molecular Formula
- C6H10ClNO2
- Formula Weight
- 163.6021
- MOL File
- 6027-91-4.mol
GUVACINE HYDROCHLORIDE Property
- Melting point:
- 316 °C (decomp)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- H2O: soluble
- form
- solid
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23361
- Product name
- Guvacine (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 23361
- Product name
- Guvacine (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 23361
- Product name
- Guvacine (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 23361
- Product name
- Guvacine (hydrochloride)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- G876400
- Product name
- Guvacine hydrochloride
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
GUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Beige Solid
Uses
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Uses
Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.
Biological Activity
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
in vitro
Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
GUVACINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
GUVACINE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from GUVACINE HYDROCHLORIDE manufacturers
- Product
- GUVACINE HYDROCHLORIDE 6027-91-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-24