GW4869

ChemicalBook > CAS DataBase List > GW4869

Product Name: GW4869
CAS No.: 6823-69-4
Chemical Name: GW4869
Synonyms: GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW69A， GW554869A;GW4869 USP/EP/BP;N-SMase Inhibitor
CBNumber: CB4972736
Molecular Formula: C30H29ClN6O2
Formula Weight: 541.05
MOL File: 6823-69-4.mol

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GW4869 Property

Melting point:: >300 °C
storage temp.: 2-8°C
solubility: DMSO: soluble0.2mg/mL
form: powder
color: light yellow to yellow

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D1692
Product name: GW4869
Purity: ≥90% (NMR)
Packaging: 5mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 13127
Product name: GW 4869 (hydrochloride hydrate)
Purity: ≥90%
Packaging: 500μg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 13127
Product name: GW 4869 (hydrochloride hydrate)
Purity: ≥90%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Sigma-Aldrich

Product number: D1692
Product name: GW4869
Purity: ≥90% (NMR)
Packaging: 25mg
Price: $851
Updated: 2024/03/01

Cayman Chemical

Product number: 13127
Product name: GW 4869 (hydrochloride hydrate)
Purity: ≥90%
Packaging: 5mg
Price: $160
Updated: 2024/03/01

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GW4869 Chemical Properties,Usage,Production

Uses

GW4869 has been used:

as an inhibitor of neutral sphingomyelinase and exosome biogenesis
to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
to determine the contributions of p75 neurotrophin receptor (p75^NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats

General Description

GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs).

Biochem/physiol Actions

A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)

GW4869 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW4869 Suppliers

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View Lastest Price from GW4869 manufacturers

Dideu Industries Group Limited

Product: GW4869 6823-69-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

Career Henan Chemical Co

Product: GW4869 6823-69-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

6823-69-4, GW4869Related Search:

N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem

CS-2410

N-SMase Inhibitor

2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2)

4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride

GW 4869 (hydrochloride hydrate)

GW4869/GW-4869

GW4869 dihydrochloride

GW4869;GW 4869 HYDROCHLORIDE HYDRATE

GW4869(1)

GW4869(2)

GW69A， GW554869A

GW4869 USP/EP/BP

GW4869 2HCl

p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride

GW4869 HCl

GW-4869,Inhibitor,Phospholipase,GW4869,inhibit

6823-69-4

C30H28N6O22HCl

C30H30N6Cl2O2

API

A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase.