GW4869
- Product Name
- GW4869
- CAS No.
- 6823-69-4
- Chemical Name
- GW4869
- Synonyms
- GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW69A， GW554869A;GW4869 USP/EP/BP;N-SMase Inhibitor
- CBNumber
- CB4972736
- Molecular Formula
- C30H29ClN6O2
- Formula Weight
- 541.05
- MOL File
- 6823-69-4.mol
GW4869 Property
- Melting point:
- >300 °C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble0.2mg/mL
- form
- powder
- color
- light yellow to yellow
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2933299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D1692
- Product name
- GW4869
- Purity
- ≥90% (NMR)
- Packaging
- 5mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 500μg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- D1692
- Product name
- GW4869
- Purity
- ≥90% (NMR)
- Packaging
- 25mg
- Price
- $851
- Updated
- 2024/03/01
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
GW4869 Chemical Properties,Usage,Production
Uses
GW4869 has been used:
- as an inhibitor of neutral sphingomyelinase and exosome biogenesis
- to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
- to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
General Description
GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs).
Biochem/physiol Actions
A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)
GW4869 Preparation Products And Raw materials
Raw materials
Preparation Products
GW4869 Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from GW4869 manufacturers
- Product
- GW4869 6823-69-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17
- Product
- GW4869 6823-69-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20