PRL-3 INHIBITOR I
- Product Name
- PRL-3 INHIBITOR I
- CAS No.
- 893449-38-2
- Chemical Name
- PRL-3 INHIBITOR I
- Synonyms
- P0180;PRL-3 Inhibitor;PRL-3 INHIBITOR I;PRL-3 Inhibitor - CAS 893449-38-2 - Calbiochem;Phosphatase of regenerating liver-3, Inhibitor I;5-(5-Bromo-2-((2-bromobenzyl)oxy)benzylidene)-2-thioxothiazolidin-4-one;5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-;cells,Inhibitor,PRL3 Inhibitor I,invasion,inhibit,PRL-3 Inhibitor I,melanoma,PRL 3 Inhibitor I,B16F10,Phosphatase;Phosphatase of regenerating liver-3, Inhibitor I, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
- CBNumber
- CB4972918
- Molecular Formula
- C17H11Br2NO2S2
- Formula Weight
- 485.21
- MOL File
- 893449-38-2.mol
PRL-3 INHIBITOR I Property
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: >10mg/mL
- form
- Yellow solid
- pka
- 7.11±0.50(Predicted)
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50/53
- Safety Statements
- 26-36/37-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P0108
- Product name
- PRL-3 Inhibitor I
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 18719
- Product name
- PRL-3 Inhibitor
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18719
- Product name
- PRL-3 Inhibitor
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 18719
- Product name
- PRL-3 Inhibitor
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 18719
- Product name
- PRL-3 Inhibitor
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $267
- Updated
- 2024/03/01
PRL-3 INHIBITOR I Chemical Properties,Usage,Production
Description
P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1? Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.4
Uses
5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone is a a cell-permeable benzylidene rhodamine that inhibits Phosphatase of regenerating liver 3 (PRL-3).
Definition
ChEBI: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one is an aromatic ether.
in vitro
prl-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of difmup by prl-3 and strongly suppressed the activity of prl-3 phosphatase in prl-3 overexpressing dld-1 colon tumor cells [dld-1 (prl-3)]. also, prl-3 inhibitor dose-dependently blocked the migration of dld-1 (prl-3) cells, however, it did not inhibit the proliferation of dld-1(prl-3) cells, suggesting that prl-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity [1].
IC 50
900 nm: blocks human phosphatase of regenerating liver 3 (prl-3) in vitro.
References
1) Ahn et al. (2006), Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors; Bioorg. Med. Chem. Lett., 16 2996 2) Min et al. (2013), Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells; Bioorg. Med. Chem. Lett., 23 3769 3) Zhao et al. (2011), PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy; PLoS One, 6(5) e19798 4) Tian et al. (2012), Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783; BMC Biochemistry, 13 22
PRL-3 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
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