Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Property

Boiling point:

433.1±45.0 °C(Predicted)

Density 

1.330±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 100 mg/mL (323.43 mM; Need ultrasonic)

form 

Solid

pka

13.54±0.46(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties,Usage,Production

Biological Activity

RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1].

References

[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.