FMOC-TYR-OME
- Product Name
- FMOC-TYR-OME
- CAS No.
- 82911-79-3
- Chemical Name
- FMOC-TYR-OME
- Synonyms
- FMOC-TYR-OME;Fmoc-L-Tyr-OMe;Fmoc-L-tyrosine Methyl Ester;N-Fmoc-L-tyrosine methyl ester;METHYL D-AMINOLEVULINATE HYDROCHLORIDE;(9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr-OMe;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosine methyl ester;L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester;(S)-Methyl 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-hydroxyphenyl)propanoate;methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxyphenyl)propanoate
- CBNumber
- CB51005414
- Molecular Formula
- C25H23NO5
- Formula Weight
- 417.45
- MOL File
- 82911-79-3.mol
FMOC-TYR-OME Property
- Melting point:
- 122-123 °C
- Boiling point:
- 645.2±55.0 °C(Predicted)
- Density
- 1.275±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.75±0.15(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- 32.668° (C=0.01 g/ml, CHCL3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AS102819
- Product name
- N-Fmoc-L-tyrosine methyl ester
- Purity
- 95% ee
- Packaging
- 5G
- Price
- $88
- Updated
- 2021/12/16
- Product number
- Y3480
- Product name
- Fmoc-Tyr-Ome
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- AS102819
- Product name
- N-Fmoc-L-tyrosine methyl ester
- Purity
- 95% ee
- Packaging
- 25g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- AAA0010615
- Product name
- FMOC-TYR-OME
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.13
- Updated
- 2021/12/16
- Product number
- AS102819
- Product name
- N-Fmoc-L-tyrosine methyl ester
- Purity
- 95% ee
- Packaging
- 100g
- Price
- $683
- Updated
- 2021/12/16
FMOC-TYR-OME Chemical Properties,Usage,Production
Synthesis
1240497-07-7
82911-79-3
GENERAL PROCEDURE: METHOD A-USE OF PLANETARY BALL MILL: Triphenylmethylated compounds (1 mmol; typically 563 mg, 4) and In(OTf)3 (141 mg, 0.25 mmol) were mixed in a 50 mL stainless steel (SS) jar with ten 10-mm diameter SS balls. The reaction was carried out in a planetary ball mill (PM-100) at 550 rpm for 3.5 h (the progress of the reaction was monitored by TLC and the unfolding agent was EtOAc:Hex, 1:1). Upon completion of the reaction, EtOAc was added to the mixture and the solution was transferred to a dispensing funnel (50 ml × 3). The organic phase was washed sequentially with 10% Na2CO3 aqueous solution (50 ml × 2) and water (50 ml), dried with Na2SO4 and concentrated under reduced pressure to obtain the crude de-O-tritylated product. The crude product was purified by fast chromatography to remove the by-product TrOH to give the pure product (yield: 305 mg, 95.2%, 5 from 4). The pure product was crystallized from ether-n-Hex to give an analytically pure product. The spectral data of the product was in agreement with the expected structure and literature values. Method B-Use of a Vibratory Ball Mill: the triphenylmethylated compound (1 mmol; typically 563 mg, 4) and In(OTf)3 (141 mg, 0.25 mmol) were mixed in a 10 mL stainless steel (SS) jar to which 20 SS balls of 3 mm diameter were added. The reaction was carried out in a vibrating ball mill (MM-400) at 30 Hz for 15 min (the progress of the reaction was monitored by TLC and the unfolding agent was EtOAc/Hex, 1:1). The post-treatment and isolation steps of the product were the same as in Method A. The yield was 308 mg, 96.2%, from 4 to 5.
References
[1] Carbohydrate Research, 2014, vol. 397, p. 18 - 26
FMOC-TYR-OME Preparation Products And Raw materials
Raw materials
Preparation Products
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