Background

Kava Kava Extract

Background
Product Name
Kava Kava Extract
Chemical Name
Kava Kava Extract
Synonyms
Kava extract
CBNumber
CB51006789
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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Kava Kava Extract Chemical Properties,Usage,Production

Background

Kava Kava is a tropical shrub belonging to the family Piperaceae. It is widely cultivated for its rootstock in three geographic regions of the Pacific: Polynesia, Melanesia, and Micronesia, although it is also widely cultivated in North African countries such as Morocco, Tunisia, Egypt, etc., where it is used as a ritual beverage to promote relaxation and a sense of well-being. Approximately 2.2 million Americans used Kava Kava as a natural alternative to antianxiety drugs, used as a diuretic and antiseptic, and it has been reported to help children with hyperactivity. The recommended oral dose for usage of Kava Kava as an anxiolytic is 50–70 mg of kavalactones two to four times a day and, as a hypnotic, 150–210 mg in a single oral dose before bedtime. The active principles of Kava Kava rootstock are mostly contained in the lipid-soluble resin, which is generally grouped into categories, namely: arylethylene-apyrones, chalcones and other flavanones, and conjugated diene ketones. The compounds of greatest pharmacological interest are the substituted α-pyrones or Kava pyrones, commonly known as kavalactones. Fifteen lactones have been isolated from Kava Kava rootstock, of which six are present in the highest concentrations and account for approximately 96% of the lipid resin. These are yangonin, methysticin, dihydromethysticin, kavain, dihydrokavain, and desmethoxyyangonin.

Health effects

Kava is the most commonly cited herb related to liver toxicity. Kava, an herbal sedative with antianxiety or calming effects, is prepared by extracting the rhizomes of Piper methysticum, a South Pacific plant. The active ingredients of the plant, known as kavalactones, are found mostly in the rhizomes. Early scientific research indicated that kava was as efficacious as antidepressant drugs and tranquillizers in treating anxiety disorders. In fact, kava extracts were considered safe alternatives to drug therapy for treating anxiety disorders before 1998. However, by 2003, 11 cases of hepatic failure had been reported related to the use of kava, including 7 patients requiring liver transplantation and 4 deaths. In 2003, kava was banned in the European Union and Canada, and the FDA issued another warning. By 2009, more than 100 cases of hepatotoxicity had been linked to kava exposure. Many have followed co-ingestion with alcohol, which appears to potentiate the hepatoxicity.

Kava Kava Extract Preparation Products And Raw materials

Raw materials

Preparation Products

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Kava Kava Extract Suppliers

Shaanxi Xintianyu Biotechnology Co., Ltd
Tel
18165211053 18165211053
Email
1039932273@qq.com
Country
China
ProdList
1008
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58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8861
Advantage
60
Rixing Chemical CO.,LTD.
Tel
+86-852-57055271 +8613237129059
Fax
-
Email
sales@rixingbiz.com
Country
China
ProdList
232
Advantage
58
Zhuoer Chemical Co., Ltd
Tel
02120970332; +8613524231522
Fax
+86-21-58816016
Email
sales@zhuoerchem.com
Country
China
ProdList
2904
Advantage
58
Shaanxi xintianyu Biotechnology Co., Ltd.
Tel
17749282610
Fax
029-32562222
Email
3002817800@qq.com
Country
China
ProdList
981
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81024372 15029046529
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10009
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
18080489829
Email
3004654993@qq.com
Country
China
ProdList
9209
Advantage
58
Hubei Hengluyuan Technology co.ltd
Tel
027-88188016 18717196322
Email
1764683941@qq.com
Country
China
ProdList
5749
Advantage
58