ChemicalBook > CAS DataBase List > 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Product Name: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID
CAS No.: 1123-28-0
Chemical Name: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID
Synonyms: 1-Hydroxycyclohexanecarboxylic acid;1-hydroxycyclohexane-1-carboxylic acid;1-Hydroxycyclohexenecarboxylic acid;Cyclohexanecarboxylicacid, 1-hydroxy-;1-hydroxy-Cyclohexane carbocylic acid;1-hydroxycyclohexanecarboxylic acid(SALTDATA: FREE)
CBNumber: CB51009669
Molecular Formula: C7H12O3
Formula Weight: 144.17
MOL File: 1123-28-0.mol

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1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID Property

Melting point:: 107-108 °C
Boiling point:: 102 °C(Press: 14 Torr)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.99±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: H905360
Product name: 1-HydroxycyclohexanecarboxylicAcid
Packaging: 500mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 409861
Product name: 1-Hydroxycyclohexanecarboxylic Acid
Packaging: 100mg
Price: $355
Updated: 2021/12/16

Matrix Scientific

Product number: 037242
Product name: 1-Hydroxycyclohexanecarboxylic acid
Packaging: 500mg
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR951583
Product name: 1-Hydroxy-cyclohexanecarboxylic acid
Packaging: 1g
Price: $102
Updated: 2021/12/16

Apolloscientific

Product number: OR951583
Product name: 1-Hydroxy-cyclohexanecarboxylic acid
Packaging: 5g
Price: $176
Updated: 2021/12/16

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1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Yellow powder

Uses

1-Hydroxycyclohexanecarboxylic Acid is used as a reagent in the synthesis of tetronic acid carboxylate derivatives which have acaricidal acitivity.

Synthesis

931-97-5

1123-28-0

1. A solution of sodium metabisulfite (4.84 g, 0.025 mol) in distilled water (20 mL) was added slowly and dropwise to a stirred mixture of cyclohexanone (4.02 g, 0.041 mol) and potassium cyanide (3.3 g, 0.051 mol) in water (20 mL) over a period of 30 minutes. The reaction mixture was stirred continuously at 25°C for 8 hours. Upon completion of the reaction, the mixture was extracted with ethyl acetate (2 x 100 mL), the organic phases were combined and dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to give 3.8 g of 1-hydroxycyclohexanecarbonitrile as an oil. 2. 1-hydroxycyclohexanecarbonitrile obtained above was dissolved in acetic acid (12.5 mL) and diluted slowly by adding concentrated hydrochloric acid (37.5 mL). The reaction solution was heated to reflux for 6 hours and subsequently concentrated under reduced pressure to an oily residue. The residue was partitioned between water (50 mL) and ethyl acetate (50 mL), the organic phase was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a solid. The solid was washed with hexane (25 mL) and filtered to give 2.84 g of 1-hydroxycyclohexanecarboxylic acid. 3. 1-Hydroxycyclohexanecarboxylic acid was dissolved in methanol (50 mL) and catalyzed by adding a drop of concentrated sulfuric acid. The reaction solution was heated to reflux for 16 hours and subsequently concentrated under reduced pressure to an oily residue. The residue was dissolved in ethyl acetate (50 mL) and washed with 5% sodium bicarbonate solution (50 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered, concentrated under reduced pressure, and finally purified by silica gel column chromatography (eluent: 80% hexane/20% ethyl acetate) to afford 2.71 g of 1-hydroxycyclohexanecarboxylic acid methyl ester as a clear colorless oil.

References

[1] Egyptian Journal of Chemistry, 2010, vol. 53, # 5, p. 745 - 755
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1877 - 1880
[3] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 129,135, 150
[4] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1907, vol. 144, p. 329
[5] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1909, vol. 149, p. 605

1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID 1123-28-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID 1123-28-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID 1123-28-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

1123-28-0, 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACIDRelated Search:

CYNARIN Quinic acid 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID Vinflunine Valrubicin Chlorogenic acid Isochlorogenic acid A Vincristine sulfate Formyl-leurosine Cyclohexanecarboxylic acid, 3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxy-, monopotassium salt, [1S-(1alpha,3beta,4alpha,5alpha)]-, compd. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (1:1) 4-Desacetyl Vinblastine VINCRISTINE SULFATE [3H(G)] Vinepidine 6,7-DIMETHYL-4-OXATRICYCLO[4.3.0.0(3,7)]NONANE-3-CARBOXYLIC ACID VINBLASTINE, SULFATE, [3H]- [G-3H]VINBLASTINE SULFATE (-)-4,5-O-CYCLOHEXYLIDENEQUINIC ACID LACTONE Cynarine

1-Hydroxycyclohexenecarboxylic acid

1-hydroxy-Cyclohexane carbocylic acid

Cyclohexanecarboxylicacid, 1-hydroxy-

1-Hydroxycyclohexanecarboxylic acid

1-hydroxycyclohexane-1-carboxylic acid

1-hydroxycyclohexanecarboxylic acid(SALTDATA: FREE)

1123-28-0