ChemicalBook > CAS DataBase List > METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
Uses- Product Name
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
- CAS No.
- 10315-06-7
- Chemical Name
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
- Synonyms
- N-benzyl -4-Methyl piperidine;MethylN-benzylisonipecotinate;1-benzyl-4-piperidinecarboxylate;Methyl-benzylpiperidine-4-carboxylate;N-Benzylisonipecotic acid methyl ester;Methyl 1-benzyl-4-piperidinecarboxylate;METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE;Methyl N-benzylpiperidine-4-carboxylate;1-Benzyl-4-piperidinecarboxylatemethylester;N-benzylpiperidine-4-carboxylate, methyl ester
- CBNumber
- CB51012067
- Molecular Formula
- C14H19NO2
- Formula Weight
- 233.31
- MOL File
- 10315-06-7.mol
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METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Property
- Boiling point:
- 115 °C
- Density
- 1.093±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 7.86±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C14H19NO2/c1-17-14(16)13-7-9-15(10-8-13)11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
- InChIKey
- MXOZSPRDEKPWCW-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=CC=C2)CCC(C(OC)=O)CC1
- CAS DataBase Reference
- 10315-06-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- M332040
- Product name
- Methyl1-Benzylpiperidine-4-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0068335
- Product name
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $707.02
- Updated
- 2021/12/16
Rieke Metals
- Product number
- NV02012
- Product name
- METHYL1-BENZYLPIPERIDINE-4-CARBOXYLATE
- Packaging
- 1g
- Price
- $809
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0068335
- Product name
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $958.94
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0068335
- Product name
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1143.68
- Updated
- 2021/12/16
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METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Chemical Properties,Usage,Production
Uses
The preparation of donepezil hydrochloride using 1-benzyl-4-piperidinecarboxaldehyde as an intermediate has been widely studied and applied. Donepezil hydrochloride is a long-acting symptomatic treatment for Alzheimer's disease (AD).
Chemical Properties
Colorless liquid
Synthesis
2971-79-1
100-39-0
10315-06-7
Methyl 4-piperidinecarboxylate (10.00 g, 6.4 mmol) and triethylamine (10.32 g, 10.2 mmol) were dissolved in chloroform (100 mL), and benzyl bromide (14.69 g, 8.6 mmol) was slowly added under argon protection while the reaction mixture was cooled with water and an ice bath. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, chloroform and water were added to separate the two phases. The aqueous phase was further extracted with chloroform. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to dryness under reduced pressure to give 13.80 g of methyl 1-benzyl-4-piperidinecarboxylate as an orange solid (yield: 88%).
References
[1] Arkivoc, 2010, vol. 2010, # 10, p. 132 - 148
[2] Patent: WO2004/76450, 2004, A1. Location in patent: Page 43-44
[3] Synthesis, 2002, # 7, p. 911 - 915
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 4324 - 4338
METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
- Price
- US $6.00-4.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-06-11
Shaanxi Dideu Medichem Co. Ltd
- Product
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2019-12-30
Wuhan Xinhao Biotechnology Co., Ltd
- Product
- METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-03-20
10315-06-7, METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATERelated Search:
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ETHYL 1-(4-CHLOROBENZOYL)-4-PIPERIDINECARBOXYLATE
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Ethyl1-(4-Bromo-benzyl)-piperidine-4-carboxylate
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BUTTPARK 91\15-62